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MedKoo Cat#: 551007 | Name: LP10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LP10 is a reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1 and a Potent type II inhibitor of Trypanosoma cruzi CYP51.

Chemical Structure

LP10
LP10
CAS#1025400-45-6

Theoretical Analysis

MedKoo Cat#: 551007

Name: LP10

CAS#: 1025400-45-6

Chemical Formula: C24H28N4O2

Exact Mass: 404.2212

Molecular Weight: 404.51

Elemental Analysis: C, 71.26; H, 6.98; N, 13.85; O, 7.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LP10; LP-10; LP 10.
IUPAC/Chemical Name
α-​[[(4-​Methylcyclohexyl)​carbonyl]​amino]​-​N-​4-​pyridinyl-1H-​indole-​3-​propanamide
InChi Key
ICFUCABJWQGTGU-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H28N4O2/c1-16-6-8-17(9-7-16)23(29)28-22(24(30)27-19-10-12-25-13-11-19)14-18-15-26-21-5-3-2-4-20(18)21/h2-5,10-13,15-17,22,26H,6-9,14H2,1H3,(H,28,29)(H,25,27,30)
SMILES Code
O=C(NC1=CC=NC=C1)C(NC(C2CCC(C)CC2)=O)CC3=CNC4=C3C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 404.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Conner KP, Cruce AA, Krzyaniak MD, Schimpf AM, Frank DJ, Ortiz de Montellano P, Atkins WM, Bowman MK. Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. Biochemistry. 2015 Feb 10;54(5):1198-207. doi: 10.1021/bi501402k. Epub 2015 Jan 29. PubMed PMID: 25591012; PubMed Central PMCID: PMC4437715. 2: Ouellet H, Kells PM, Ortiz de Montellano PR, Podust LM. Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1. Bioorg Med Chem Lett. 2011 Jan 1;21(1):332-7. doi: 10.1016/j.bmcl.2010.11.007. Epub 2010 Nov 5. PubMed PMID: 21109436; PubMed Central PMCID: PMC3011832.