WNK463, also known as NVP-WNK463, is a potent and orally bioavailable pan-WNK-kinase inhibitor. WNK463 affects blood pressure and body fluid and electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology. The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis.
MedKoo Cat#: 530659
Name: WNK463
CAS#: 2012607-27-9
Chemical Formula: C21H24F3N7O2
Exact Mass: 463.1944
Molecular Weight: 463.47
Elemental Analysis: C, 54.42; H, 5.22; F, 12.30; N, 21.16; O, 6.90
The following data is based on the product molecular weight 463.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
