AG-7404 is a potent protease inhibitor with Anti-poliovirus activity. AG-7404 is active against all virus with EC50 values ranging from 0.080 to 0.674 μM. AG-7404 was fully active against all V-073-resistant variants, with EC₅₀ values ranging from 0.218 to 0.819 μM, compared to values of 0.202-0.407 μM for the V-073-susceptible parental strains. In vitro drug combination experiments demonstrated synergy between AG-7404 and either V-073 or BTA798, whereas the combination of the two capsid inhibitors acted additively.
MedKoo Cat#: 530656
Name: AG-7404
CAS#: 343565-99-1
Chemical Formula: C26H29N5O7
Exact Mass: 523.2067
Molecular Weight: 523.55
Elemental Analysis: C, 59.65; H, 5.58; N, 13.38; O, 21.39
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.0 | 0.00 |
The following data is based on the product molecular weight 523.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
