MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 531025 | Name: Hematein
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hematein, also known as Haematein, is an oxidized derivative of Hematoxylin (Haematoxylin) used in staining the staining of cell nuclei in animal tissue. Hematein also can be used in the staining of myelin sheaths and nerve fibers. This product has low purity ( the estimated HPLC purity is ~ 50%).

Chemical Structure

Hematein
Hematein
CAS#475-25-2

Theoretical Analysis

MedKoo Cat#: 531025

Name: Hematein

CAS#: 475-25-2

Chemical Formula: C16H12O6

Exact Mass: 300.0634

Molecular Weight: 300.27

Elemental Analysis: C, 64.00; H, 4.03; O, 31.97

Price and Availability

Size Price Availability Quantity
1g USD 150.00 Ready to ship
5g USD 350.00 Ready to ship
10g USD 550.00 Ready to ship
25g USD 1,150.00 Ready to ship
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
475-25-2 (Hematein) 517-28-2 (Hematoxylin)
Synonym
Hematein, haematein, Hematoxylin, Haematoxylin, AI3-63013, AI3 63013, AI363013, NSC 7333, NSC-7333, NSC7333,
IUPAC/Chemical Name
3,4,6a,10-tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one
InChi Key
HLUCICHZHWJHLL-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,17,19-21H,5-6H2
SMILES Code
O=C1C=C2CC3(O)C(C4=CC=C(O)C(O)=C4OC3)=C2C=C1O
Appearance
Light brown to brown solid powder.
Purity
CORRESPONDS TO STANDARD (the estimated HPLC purity is ~ 50%)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#S9G02M13
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 300.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Panayotacopoulou MT, Boukis D, Issidorides MR. Localization of phospholipids in human catecholamine neurons with Baker's acid haematein. J Neurocytol. 1989 Oct;18(5):593-7. PubMed PMID: 2482342. 2: Elleder M, Lojda Z. Studies in lipid histochemistry. II. The nature of the material stained with acid haematein test and with OTAN reaction in red blood cells. Histochemie. 1970;24(1):21-8. PubMed PMID: 4098193. 3: Roozemond RC. A comparison of the Baker acid Haematein staining of selected regions of rat hypothalamus with the fatty acid composition of their phosphatidyl choline content and their polar lipid fraction as determined by gas liquid chromatography. Histochem J. 1970 May;2(3):219-30. PubMed PMID: 4112993. 4: CAIN AJ. An examination of Baker's acid haematein test for phospholipines. Q J Microsc Sci. 1947 Dec;88(Pt 4):467-78. PubMed PMID: 18904463. 5: LANE NJ. VISUALIZATION OF SITES OF PHOSPHATASE ACTIVITIES BY MEANS OF MORDANTED HAEMATEIN. J Histochem Cytochem. 1965 Mar;13:235-8. PubMed PMID: 14327696. 6: Kroon DB, Goossens EM. The demonstration of phospholipids in certain cells in neurosecretory nuclei in the rat with Baker's acid Haematein after Fixation in glutaraldehyde-formol-calcium. Z Zellforsch Mikrosk Anat. 1967;83(4):527-37. PubMed PMID: 4177719. 7: KROON DB. CERTAIN CELLS IN THE HYPOTHALAMIC NEUROSECRETORY NUCLEI WHICH ARE STAINABLE BY THE ACID-HAEMATEIN TEST FOR PHOSPHOLIPIDS ACCORDING TO BAKER. Z Zellforsch Mikrosk Anat. 1963 Nov 21;61:317-37. PubMed PMID: 14104678. 8: Bronzato M, Zoleo A, Biondi B, Centeno SA. An insight into the metal coordination and spectroscopic properties of artistic Fe and Fe/Cu logwood inks. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:522-9. doi: 10.1016/j.saa.2015.08.042. Epub 2015 Sep 3. PubMed PMID: 26414555. 9: Wu Y, Tang L, Huang L, Han Z, Wang J, Pan H. A low detection limit penicillin biosensor based on single graphene nanosheets preadsorbed with hematein/ionic liquids/penicillinase. Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:92-9. doi: 10.1016/j.msec.2014.02.012. Epub 2014 Feb 17. PubMed PMID: 24863203. 10: Dapson RW, Bain CL. Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. Biotech Histochem. 2015;90(6):401-23. doi: 10.3109/10520295.2015.1021381. Epub 2015 Apr 20. Review. PubMed PMID: 25893688. 11: Liu H, Jiang H, Xia B, Yi D. The Research of Feature Extraction Method of Liver Pathological Image Based on Multispatial Mapping and Statistical Properties. Comput Math Methods Med. 2016;2016:8420350. doi: 10.1155/2016/8420350. Epub 2016 Feb 28. PubMed PMID: 27022407; PubMed Central PMCID: PMC4789065. 12: Commandeur F, Acosta O, Simon A, Mathieu R, Fautrel A, Gnep K, Haigron P, de Crevoisier R. Prostate whole-mount histology reconstruction and registration to MRI for correlating in-vivo observations with biological findings. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:2399-402. doi: 10.1109/EMBC.2015.7318877. PubMed PMID: 26736777. 13: Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons DM, You L. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol. 2013 Nov;43(5):1517-22. doi: 10.3892/ijo.2013.2087. Epub 2013 Sep 4. PubMed PMID: 24008396; PubMed Central PMCID: PMC3823374. 14: Smith AA. Hematein chelates of unusual metal ions for tinctorial histochemistry. Biotech Histochem. 2010 Feb;85(1):43-54. doi: 10.3109/10520290903048392. PubMed PMID: 19575317. 15: Kiernan JA, Horobin RW. A special issue devoted to hematoxylin, hematein, and hemalum. Biotech Histochem. 2010 Feb;85(1):5-6. doi: 10.3109/10520290903048368. PubMed PMID: 19548134. 16: Chen B, Ma M, Su X. An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode. Anal Chim Acta. 2010 Jul 26;674(1):89-95. doi: 10.1016/j.aca.2010.06.014. Epub 2010 Jun 16. PubMed PMID: 20638504. 17: Cooksey C. Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. Biotech Histochem. 2010 Feb;85(1):65-82. doi: 10.3109/10520290903048418. PubMed PMID: 19568968. 18: Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L. Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. BMC Cancer. 2009 May 6;9:135. doi: 10.1186/1471-2407-9-135. PubMed PMID: 19419583; PubMed Central PMCID: PMC2696466. 19: Carpentier P, Foquin A, Dorandeu F. A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus. Neurotoxicology. 2012 Aug;33(4):789-95. doi: 10.1016/j.neuro.2011.11.007. Epub 2011 Dec 3. PubMed PMID: 22155333. 20: Marshall PN. Papanicolaou staining--a review. Microsc Acta. 1983 May;87(3):233-43. Review. PubMed PMID: 6195507.

View History

Kebuzone

Kebuzone