MedKoo Cat#: 526380 | Name: B022
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

B022 is a novel inhibitor of NF-kappaB-inducing kinase (NIK), protecting liver from toxin-induced inflammation, oxidative stress, and injury.

Chemical Structure

B022
B022
CAS#1202764-53-1

Theoretical Analysis

MedKoo Cat#: 526380

Name: B022

CAS#: 1202764-53-1

Chemical Formula: C19H16ClN5OS

Exact Mass: 397.0764

Molecular Weight: 397.88

Elemental Analysis: C, 57.36; H, 4.05; Cl, 8.91; N, 17.60; O, 4.02; S, 8.06

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
B022; B-022; B 022;
IUPAC/Chemical Name
4-[1-(2-Amino-5-chloro-pyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-thiazol-2-yl-but-3-yn-2-ol
InChi Key
OKFYOOFXVBCIIP-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H16ClN5OS/c1-19(26,17-22-7-9-27-17)6-4-12-2-3-13-5-8-25(15(13)10-12)16-14(20)11-23-18(21)24-16/h2-3,7,9-11,26H,5,8H2,1H3,(H2,21,23,24)
SMILES Code
CC(O)(C1=NC=CS1)C#CC2=CC3=C(C=C2)CCN3C4=NC(N)=NC=C4Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 397.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ren X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y, Chen Z. A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury. FASEB J. 2017 Feb;31(2):711-718. doi: 10.1096/fj.201600840R. Epub 2016 Nov 8. PubMed PMID: 27871061.