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MedKoo Cat#: 526296 | Name: Apoptosis inducer 5d

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Apoptosis inducer 5d is a novel inducer of cell death by activating apoptosis in cancer cells.

Chemical Structure

Apoptosis inducer 5d
Apoptosis inducer 5d
CAS#60925-00-0

Theoretical Analysis

MedKoo Cat#: 526296

Name: Apoptosis inducer 5d

CAS#: 60925-00-0

Chemical Formula: C20H14BrN3

Exact Mass: 375.0371

Molecular Weight: 376.26

Elemental Analysis: C, 63.84; H, 3.75; Br, 21.24; N, 11.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Apoptosis inducer 5d
IUPAC/Chemical Name
3-[1-(4-Bromo-phenyl)-5-phenyl-1H-pyrazol-3-yl]-pyridine
InChi Key
TZHWETVMXQTIER-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H14BrN3/c21-17-8-10-18(11-9-17)24-20(15-5-2-1-3-6-15)13-19(23-24)16-7-4-12-22-14-16/h1-14H
SMILES Code
BrC1=CC=C(N2N=C(C3=CC=CN=C3)C=C2C4=CC=CC=C4)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fernández-Laso V, Sastre C, Valdivielso JM, Betriu A, Fernández E, Egido J, Martín-Ventura JL, Blanco-Colio LM. Soluble TWEAK and Major Adverse Cardiovascular Events in Patients with CKD. Clin J Am Soc Nephrol. 2016 Mar 7;11(3):413-22. doi: 10.2215/CJN.07900715. Epub 2016 Jan 4. PubMed PMID: 26728587; PubMed Central PMCID: PMC4791813. 2: Kemnitzer W, Sirisoma N, May C, Tseng B, Drewe J, Cai SX. Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3536-40. doi: 10.1016/j.bmcl.2009.04.145. Epub 2009 May 5. PubMed PMID: 19464890. 3: Drewe J, Kasibhatla S, Tseng B, Shelton E, Sperandio D, Yee RM, Litvak J, Sendzik M, Spencer JR, Cai SX. Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-th iazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4987-90. Epub 2007 Jun 6. PubMed PMID: 17562361.