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MedKoo Cat#: 526197 | Name: DIM

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DIM is an inducer of CYP3A4 and MDR1 gene expression by activating human PXR.

Chemical Structure

DIM
CAS#1968-05-4

Theoretical Analysis

MedKoo Cat#: 526197

Name: DIM

CAS#: 1968-05-4

Chemical Formula: C17H14N2

Exact Mass: 246.1157

Molecular Weight: 246.31

Elemental Analysis: C, 82.90; H, 5.73; N, 11.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DIM
IUPAC/Chemical Name
3,3'-Methylenebis-1H-indole
InChi Key
VFTRKSBEFQDZKX-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
SMILES Code
C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang H, Seo SG, Shin SH, Min S, Kang MJ, Yoo R, Kwon JY, Yue S, Kim KH, Cheng JX, Kim JR, Park JS, Kim JH, Park JHY, Lee HJ, Lee KW. 3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity. Mol Nutr Food Res. 2017 Jun 6. doi: 10.1002/mnfr.201700119. [Epub ahead of print] PubMed PMID: 28586165. 2: Zhang X, Sukamporn P, Zhang S, Min KW, Baek SJ. 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells. Oncol Rep. 2017 Jun 1. doi: 10.3892/or.2017.5693. [Epub ahead of print] PubMed PMID: 28586058. 3: Diaz-Arevalo D, Kalkum M. CD4(+) T Cells Mediate Aspergillosis Vaccine Protection. Methods Mol Biol. 2017;1625:281-293. doi: 10.1007/978-1-4939-7104-6_19. PubMed PMID: 28584997. 4: Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E. The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. J Nutr Biochem. 2017 May 25;47:113-119. doi: 10.1016/j.jnutbio.2017.05.005. [Epub ahead of print] PubMed PMID: 28582660. 5: Liu K, Xin H, Settar P. Effects of light-emitting diode light v. fluorescent light on growing performance, activity levels and well-being of non-beak-trimmed W-36 pullets. Animal. 2017 Jun 5:1-10. doi: 10.1017/S1751731117001240. [Epub ahead of print] PubMed PMID: 28578737. 6: Quantin C, Collin C, Frérot M, Besson J, Cottenet J, Corneloup M, Soudry-Faure A, Mariet AS, Roussot A; pour le groupe REDSIAM–Troubles mentaux et du comportement. [Study of algorithms to identify schizophrenia in the SNIIRAM database conducted by the REDSIAM network]. Rev Epidemiol Sante Publique. 2017 May 30. pii: S0398-7620(17)30405-4. doi: 10.1016/j.respe.2017.03.133. [Epub ahead of print] French. PubMed PMID: 28576380. 7: Mason E, Pozdnyakova O, Li B, Dudley G, Dorfman DM. Flow Cytometric Patterns of CD200 and CD1d Expression Distinguish CD10-Negative, CD5-Negative Mature B-Cell Lymphoproliferative Disorders. Am J Clin Pathol. 2017 Jun 1. doi: 10.1093/ajcp/aqx041. [Epub ahead of print] PubMed PMID: 28575142. 8: Johnson EG, Albalwi AA, Al-Dabbak FM, Daher NS. Effect of Sitting Pause Times on Balance After Supine to Standing Transfer in Dim Light. J Geriatr Phys Ther. 2017 Jun 1. doi: 10.1519/JPT.0000000000000132. [Epub ahead of print] PubMed PMID: 28574915. 9: Visentin G, McParland S, De Marchi M, McDermott A, Fenelon MA, Penasa M, Berry DP. Processing characteristics of dairy cow milk are moderately heritable. J Dairy Sci. 2017 May 29. pii: S0022-0302(17)30542-8. doi: 10.3168/jds.2017-12642. [Epub ahead of print] PubMed PMID: 28571984. 10: Riedl S, Rinner B, Schaider H, Liegl-Atzwanger B, Meditz K, Preishuber-Pflügl J, Grissenberger S, Lohner K, Zweytick D. In vitro and in vivo cytotoxic activity of human lactoferricin derived antitumor peptide R-DIM-P-LF11-334 on human malignant melanoma. Oncotarget. 2017 May 11. doi: 10.18632/oncotarget.17823. [Epub ahead of print] PubMed PMID: 28570999. 11: Cuesta M, Boudreau P, Cermakian N, Boivin DB. Skin Temperature Rhythms in Humans Respond to Changes in the Timing of Sleep and Light. J Biol Rhythms. 2017 May 1:748730417702974. doi: 10.1177/0748730417702974. [Epub ahead of print] PubMed PMID: 28569119. 12: Zhang YJ, Qu W, Liu H, Wang YH, Liu CY, Li LJ, Wang HQ, Fu R, Xing LM, Shao ZH. [Research on the negative immune regulation of NK cells in patients with primary immune thrombocytopenia]. Zhonghua Xue Ye Xue Za Zhi. 2017 May 14;38(5):399-403. doi: 10.3760/cma.j.issn.0253-2727.2017.05.009. Chinese. PubMed PMID: 28565739. 13: Bobbo T, Fiore E, Gianesella M, Morgante M, Gallo L, Ruegg PL, Bittante G, Cecchinato A. Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds. Animal. 2017 May 31:1-11. doi: 10.1017/S1751731117001227. [Epub ahead of print] PubMed PMID: 28560948. 14: Thomson CA, Chow HHS, Wertheim BC, Roe DJ, Stopeck A, Maskarinec G, Altbach M, Chalasani P, Huang C, Strom MB, Galons JP, Thompson PA. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Res Treat. 2017 May 30. doi: 10.1007/s10549-017-4292-7. [Epub ahead of print] PubMed PMID: 28560655. 15: Xiang L, Chen XJ, Wu KC, Zhang CJ, Zhou GH, Lv JN, Sun LF, Cheng FF, Cai XB, Jin ZB. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017 May 30. pii: 201618757. doi: 10.1073/pnas.1618757114. [Epub ahead of print] PubMed PMID: 28559309. 16: Pode-Shakked N, Gershon R, Tam G, Omer D, Gnatek Y, Kanter I, Oriel S, Katz G, Harari-Steinberg O, Kalisky T, Dekel B. Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level. Stem Cell Reports. 2017 May 25. pii: S2213-6711(17)30180-7. doi: 10.1016/j.stemcr.2017.04.026. [Epub ahead of print] PubMed PMID: 28552604. 17: Kamata T, Giblett S, Pritchard C. KRAS(G12D) expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment. Blood. 2017 May 26. pii: blood-2017-02-770149. doi: 10.1182/blood-2017-02-770149. [Epub ahead of print] PubMed PMID: 28550040. 18: Hörl S, Ejaz A, Ernst S, Mattesich M, Kaiser A, Jenewein B, Zwierzina ME, Hammerle S, Miggitsch C, Mitterberger-Vogt MC, Krautgasser C, Pierer G, Zwerschke W. CD146 (MCAM) in human cs-DLK1(-)/cs-CD34(+) adipose stromal/progenitor cells. Stem Cell Res. 2017 May 17;22:1-12. doi: 10.1016/j.scr.2017.05.004. [Epub ahead of print] PubMed PMID: 28549249. 19: El-Tarabany MS. Impact of days in milk at the initiation of ovulation synchronization protocols on the efficiency of first AI in multiparous Holstein cows. Anim Reprod Sci. 2017 May 17. pii: S0378-4320(17)30081-7. doi: 10.1016/j.anireprosci.2017.05.005. [Epub ahead of print] PubMed PMID: 28545988. 20: Theunissen PMJ, van den Branden A, Van Der Sluijs-Gelling A, De Haas V, Beishuizen A, van Dongen JJM, Van Der Velden VHJ. Understanding the reconstitution of the B-cell compartment in bone marrow and blood after treatment for B-cell precursor acute lymphoblastic leukaemia. Br J Haematol. 2017 May 25. doi: 10.1111/bjh.14685. [Epub ahead of print] PubMed PMID: 28542787.

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