IUPAC/Chemical Name
1,2,3,4-Tetrahydro-2-[(4-methylphenyl)sulfonyl]-N-[4-[(2-pyrimidinylamino)sulfonyl]phenyl]-3-Isoquinolinecarboxamide
InChi Key
NSPZPPYCIWIANY-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H25N5O5S2/c1-19-7-11-24(12-8-19)39(36,37)32-18-21-6-3-2-5-20(21)17-25(32)26(33)30-22-9-13-23(14-10-22)38(34,35)31-27-28-15-4-16-29-27/h2-16,25H,17-18H2,1H3,(H,30,33)(H,28,29,31)
SMILES Code
O=C(C1N(S(=O)(C2=CC=C(C)C=C2)=O)CC3=C(C=CC=C3)C1)NC4=CC=C(S(=O)(NC5=NC=CC=N5)=O)C=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
563.65
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4. PubMed PMID: 26178009; PubMed Central PMCID: PMC4504130.
3: Pereira RV, Gomes Mde S, Olmo RP, Souza DM, Jannotti-Passos LK, Baba EH, Castro-Borges W, Guerra-Sá R. NEDD8 conjugation in Schistosoma mansoni: genome analysis and expression profiles. Parasitol Int. 2013 Apr;62(2):199-207. doi: 10.1016/j.parint.2012.12.009. Epub 2013 Jan 8. PubMed PMID: 23313772.
