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MedKoo Cat#: 540090 | Name: Corydaline
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corydaline is isolated from Corydalis yanhusuo. It exhibits many activities, including increaseing gastric emptying and small intestine transit seed, decreasing chemically induced pain, and potentially suppressing mast cell dependent smooth muscle contracting of the aorta.

Chemical Structure

Corydaline
CAS#518-69-4

Theoretical Analysis

MedKoo Cat#: 540090

Name: Corydaline

CAS#: 518-69-4

Chemical Formula: C22H27NO4

Exact Mass: 369.1940

Molecular Weight: 369.46

Elemental Analysis: C, 71.52; H, 7.37; N, 3.79; O, 17.32

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
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Related CAS #
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Synonym
Corydalin; Corydaline, (+)-; D-Corydaline; (+)-Corydaline; NSC 406036; NSC-406036; NSC406036
IUPAC/Chemical Name
(13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline
InChi Key
VRSRXLJTYQVOHC-YEJXKQKISA-N
InChi Code
InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1
SMILES Code
C[C@H]([C@@]1([H])N2CCC3=C1C=C(OC)C(OC)=C3)C4=C(C2)C(OC)=C(OC)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM).
In vitro activity:
Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Reference: J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133. https://pubmed.ncbi.nlm.nih.gov/29034730/
In vivo activity:
Conditioned place preference (CPP) was used to evaluate the rewarding effects of morphine and Western-blot immunoreactive assays were used to evaluate morphine-induced changes in dopamine D2 receptor and GluA1 AMPA receptor and GluA2 AMPA receptor expression in the brain of rats. Systemic administration of corydaline (5 mg/kg, i.p.) or l-THP (1.25, 2.5,5 mg/kg) significantly inhibited the acquisition and expression of morphine-induced CPP in a dose-dependent manner. Reference: Eur J Pharmacol. 2020 Oct 5;884:173397. https://pubmed.ncbi.nlm.nih.gov/32717192/
Solvent mg/mL mM comments
Solubility
DMSO 37.4 101.34
DMSO:PBS (pH 7.2) (1:5) 0.2 0.43
DMF 5.0 13.53
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 369.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wang HQ, Hu J, Yan HY, Wu S, Li YH. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133. doi: 10.1080/10286020.2017.1386658. Epub 2017 Oct 15. PMID: 29034730. 2. Ji HY, Liu KH, Lee H, Im SR, Shim HJ, Son M, Lee HS. Corydaline inhibits multiple cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Molecules. 2011 Aug 5;16(8):6591-602. doi: 10.3390/molecules16086591. PMID: 21826053; PMCID: PMC6264278. 3. Jiang WN, Jing X, Li M, Deng H, Jiang T, Xiong KZ, Chen Y, Wang XF, Wang QJ. Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor expression in rats. Eur J Pharmacol. 2020 Oct 5;884:173397. doi: 10.1016/j.ejphar.2020.173397. Epub 2020 Jul 25. PMID: 32717192.
In vitro protocol:
1. Wang HQ, Hu J, Yan HY, Wu S, Li YH. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133. doi: 10.1080/10286020.2017.1386658. Epub 2017 Oct 15. PMID: 29034730. 2. Ji HY, Liu KH, Lee H, Im SR, Shim HJ, Son M, Lee HS. Corydaline inhibits multiple cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Molecules. 2011 Aug 5;16(8):6591-602. doi: 10.3390/molecules16086591. PMID: 21826053; PMCID: PMC6264278.
In vivo protocol:
1. Jiang WN, Jing X, Li M, Deng H, Jiang T, Xiong KZ, Chen Y, Wang XF, Wang QJ. Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor expression in rats. Eur J Pharmacol. 2020 Oct 5;884:173397. doi: 10.1016/j.ejphar.2020.173397. Epub 2020 Jul 25. PMID: 32717192.
1: Jung JW, Choi MR, Kwon YS, Jeong JS, Son M, Kang HE. Gender differences in corydaline pharmacokinetics in rats. Xenobiotica. 2015 May;45(5):456-63. doi: 10.3109/00498254.2014.988772. Epub 2014 Nov 28. PubMed PMID: 25430796. 2: Ji HY, Liu KH, Lee H, Im SR, Shim HJ, Son M, Lee HS. Corydaline inhibits multiple cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Molecules. 2011 Aug 5;16(8):6591-602. doi: 10.3390/molecules16086591. PubMed PMID: 21826053. 3: Jung JW, Kim JM, Jeong JS, Son M, Lee HS, Lee MG, Kang HE. Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats. Xenobiotica. 2014 Jul;44(7):635-43. doi: 10.3109/00498254.2013.874610. Epub 2014 Jan 13. PubMed PMID: 24417753. 4: Zhang P, Xu FQ, Ma XC. [Progress for treating tachyarrhythmia by corydaline]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 May;32(5):713-6. Review. Chinese. PubMed PMID: 22679741. 5: Ji HY, Lee H, Kim JH, Kim KH, Lee KR, Shim HJ, Son M, Lee HS. In vitro metabolism of corydaline in human liver microsomes and hepatocytes using liquid chromatography-ion trap mass spectrometry. J Sep Sci. 2012 May;35(9):1102-9. doi: 10.1002/jssc.201101094. PubMed PMID: 22689485. 6: Lee TH, Son M, Kim SY. Effects of corydaline from Corydalis tuber on gastric motor function in an animal model. Biol Pharm Bull. 2010;33(6):958-62. PubMed PMID: 20522959. 7: Liu YZ, Yang XB, Yang XW, Yao CM, Ran L, Wu S, Xu W, Liu JX. [Biotransformation by human intestinal flora and absorption-transportation characteristic in a model of Caco-2 cell monolayer of d-corydaline and tetrahydropalmatine]. Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(1):112-8. Chinese. PubMed PMID: 23596886. 8: Wang J, Liang L, Zhang Q, Li X, Fu Z. Preclinical pharmacokinetics, tissue distribution and excretion studies of a potential analgesics - corydaline using an ultra performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 30;942-943:70-6. doi: 10.1016/j.jchromb.2013.10.018. Epub 2013 Oct 21. PubMed PMID: 24216274. 9: AWE W, THUM J, WICHMANN H. [Coralydine composition and Hofmann decomposition. Corydaline, synthesis from palmatine by recent methods]. Arch Pharm. 1960 Oct;293/65:907-17. German. PubMed PMID: 13685320. 10: Li L, Sun S, Weng Y, Song F, Zhou S, Bai M, Zhou H, Zeng S, Jiang H. Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3. Xenobiotica. 2016;46(2):175-83. doi: 10.3109/00498254.2015.1056283. Epub 2015 Jul 2. PubMed PMID: 26134304. 11: Tang HC, Chen CY. Drug design of cyclin-dependent kinase 2 inhibitor for melanoma from traditional Chinese medicine. Biomed Res Int. 2014;2014:798742. doi: 10.1155/2014/798742. Epub 2014 Jun 19. PubMed PMID: 25045703; PubMed Central PMCID: PMC4090515. 12: Yang LX, Zhang YX, Feng WH, Li C. [Establishment of simultaneous quantitative model of five alkaloids from Corydalis Rhizoma by near-infrared spectrometry]. Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(19):3830-7. Chinese. PubMed PMID: 26975110. 13: KONDO Y. [REACTIONS OF PROTOBERBERINE-TYPE ALKALOIDS. VII. ABSOLUTE CONFIGURATIONS OF D-THALICTRICAVINE, D-CORYDALINE, D-CORYBULBINE, AND D-ISOCORYBULBINE]. Yakugaku Zasshi. 1963 Nov;83:1017-22. Japanese. PubMed PMID: 14084786. 14: BERSCH HW. [Configuration of alkaloids of the corydaline type]. Arch Pharm Ber Dtsch Pharm Ges. 1958 Dec;291/63(11-12):595-8. German. PubMed PMID: 13617990. 15: Kametani T, Sugai T, Shoji Y, Honda T, Satoh F, Fukumoto K. Studies on the synthesis of heterocyclic compounds. Part 698. An alternative protoberberine synthesis; Total synthesis of (+/-)-xylopinine, (+/-)-schefferine, (+/-)nandinine, (+/-)-corydaline, and (+/-)-thalictricavine. J Chem Soc Perkin 1. 1977;(10):1151-5. PubMed PMID: 560382. 16: Zhang Q, Chen C, Wang FQ, Li CH, Zhang QH, Hu YJ, Xia ZN, Yang FQ. Simultaneous screening and analysis of antiplatelet aggregation active alkaloids from Rhizoma Corydalis. Pharm Biol. 2016 Dec;54(12):3113-3120. Epub 2016 Aug 25. PubMed PMID: 27558975. 17: Ai Y, Wu Y, Wang F, Ma W, Bian Q, Lee DY, Dai R. A UPLC-MS/MS method for simultaneous quantitation of three monoterpene glycosides and four alkaloids in rat plasma: application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and single herb extract. J Mass Spectrom. 2015 Mar;50(3):567-77. doi: 10.1002/jms.3563. PubMed PMID: 25800193. 18: Lu Z, Sun W, Duan X, Yang Z, Liu Y, Tu P. [Chemical constituents from Corydalis yanhusuo]. Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(2):235-7. Chinese. PubMed PMID: 22737858. 19: Xiaowen L, Ling T, Yunfei L, Guoxiang S, Dailin Y, Herry S. Simultaneous determination of seven alkaloids in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study after oral administration of Cerebralcare Granule. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 1;1017-1018:28-35. doi: 10.1016/j.jchromb.2016.01.062. Epub 2016 Feb 26. PubMed PMID: 26943262. 20: Wang S, Liu L, Wang L, Jiang P, Xiang L, Zhang W, Liu R. Development and validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of four tertiary alkaloids in rat plasma and its application to a pharmacokinetic study. J Pharm Biomed Anal. 2013 Jan;72:80-8. doi: 10.1016/j.jpba.2012.09.001. Epub 2012 Sep 11. PubMed PMID: 23146230.