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MedKoo Cat#: 540089 | Name: Corticosterone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corticosterone is an endogenous steroid hormone involved in immune responses, stress responses and energy homeostasis. It activates mineralocorticoid and glucocorticoid receptors.

Chemical Structure

Corticosterone
CAS#50-22-6

Theoretical Analysis

MedKoo Cat#: 540089

Name: Corticosterone

CAS#: 50-22-6

Chemical Formula: C21H30O4

Exact Mass: 346.2144

Molecular Weight: 346.46

Elemental Analysis: C, 72.80; H, 8.73; O, 18.47

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
250mg USD 450.00 2 Weeks
500mg USD 650.00 2 weeks
1g USD 950.00 2 weeks
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Related CAS #
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Synonym
Corticosterone; 17-deoxy Cortisol; 11β,21-DHP; BRN 2339601; BRN-233960; BRN233960; CCRIS 6753; CCRIS-6753; CCRIS6753; NSC 9705; NSC-9705; NSC9705
IUPAC/Chemical Name
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
InChi Code
InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
SMILES Code
C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
In vitro activity:
Corticosterone decreased the mRNA and protein expressions of cyclooxygenase-2. Of note, although endocannabinoids decreased cell viability, corticosterone inhibited the cannabinoid receptor agonist-induced decrease in cell viability by downregulating the mRNA and protein expressions of cannabinoid receptor 1 (CB1) in glioblastoma cells. These results suggest that corticosteroids modify the endocannabinoid system in glioblastoma cells, and a reduction in the beneficial anti-tumor effects of endocannabinoids through downregulation of the CB1 receptor by corticosterone may promote the malignant phenotype of glioblastoma. Reference: Oncol Lett. 2019 Aug;18(2):1557-1563. https://pubmed.ncbi.nlm.nih.gov/31423223/
In vivo activity:
L-CORT (low-level corticosterone) rats displayed attenuated depressive symptoms and memory defects in behavioral tests as compared with Sham or H-CORT rats. Reference: Acta Pharmacol Sin. 2021 Jun;42(6):848-860. https://pubmed.ncbi.nlm.nih.gov/33028984/
Solvent mg/mL mM comments
Solubility
DMSO 44.7 128.90
DMF 25.0 72.16
Ethanol 12.9 37.35
Ethanol:PBS (pH 7.2) (1:1) 0.5 1.44
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 346.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Sugimoto N, Ishibashi H, Ueda Y, Nakamura H, Yachie A, Ohno-Shosaku T. Corticosterone inhibits the expression of cannabinoid receptor-1 and cannabinoid receptor agonist-induced decrease in cell viability in glioblastoma cells. Oncol Lett. 2019 Aug;18(2):1557-1563. doi: 10.3892/ol.2019.10456. Epub 2019 Jun 7. PMID: 31423223; PMCID: PMC6607110. 2. Busceti CL, Ferese R, Bucci D, Ryskalin L, Gambardella S, Madonna M, Nicoletti F, Fornai F. Corticosterone Upregulates Gene and Protein Expression of Catecholamine Markers in Organotypic Brainstem Cultures. Int J Mol Sci. 2019 Jun 14;20(12):2901. doi: 10.3390/ijms20122901. PMID: 31197099; PMCID: PMC6627138. 3. Chu SF, Zhang Z, Zhou X, He WB, Yang B, Cui LY, He HY, Wang ZZ, Chen NH. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. Acta Pharmacol Sin. 2021 Jun;42(6):848-860. doi: 10.1038/s41401-020-00536-w. Epub 2020 Oct 7. PMID: 33028984; PMCID: PMC8149629. 4. Li Y, Zu Y, Li X, Zhao S, Ou F, Li L, Zhang X, Wang W, He T, Liang Y, Sun X, Tang M. Acute corticosterone treatment elicits antidepressant-like actions on the hippocampal 5-HT and the immobility phenotype. Brain Res. 2019 Jul 1;1714:166-173. doi: 10.1016/j.brainres.2019.02.022. Epub 2019 Feb 19. PMID: 30794767.
In vitro protocol:
1. Sugimoto N, Ishibashi H, Ueda Y, Nakamura H, Yachie A, Ohno-Shosaku T. Corticosterone inhibits the expression of cannabinoid receptor-1 and cannabinoid receptor agonist-induced decrease in cell viability in glioblastoma cells. Oncol Lett. 2019 Aug;18(2):1557-1563. doi: 10.3892/ol.2019.10456. Epub 2019 Jun 7. PMID: 31423223; PMCID: PMC6607110. 2. Busceti CL, Ferese R, Bucci D, Ryskalin L, Gambardella S, Madonna M, Nicoletti F, Fornai F. Corticosterone Upregulates Gene and Protein Expression of Catecholamine Markers in Organotypic Brainstem Cultures. Int J Mol Sci. 2019 Jun 14;20(12):2901. doi: 10.3390/ijms20122901. PMID: 31197099; PMCID: PMC6627138.
In vivo protocol:
1. Chu SF, Zhang Z, Zhou X, He WB, Yang B, Cui LY, He HY, Wang ZZ, Chen NH. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. Acta Pharmacol Sin. 2021 Jun;42(6):848-860. doi: 10.1038/s41401-020-00536-w. Epub 2020 Oct 7. PMID: 33028984; PMCID: PMC8149629. 2. Li Y, Zu Y, Li X, Zhao S, Ou F, Li L, Zhang X, Wang W, He T, Liang Y, Sun X, Tang M. Acute corticosterone treatment elicits antidepressant-like actions on the hippocampal 5-HT and the immobility phenotype. Brain Res. 2019 Jul 1;1714:166-173. doi: 10.1016/j.brainres.2019.02.022. Epub 2019 Feb 19. PMID: 30794767.
1: Pinson SE, Wilson JL, Navara KJ. Timing matters: corticosterone injections 4 h before ovulation bias sex ratios towards females in chickens. J Comp Physiol B. 2015 Jul;185(5):539-46. doi: 10.1007/s00360-015-0897-5. Epub 2015 Mar 15. PubMed PMID: 25774047. 2: Ebada ME, Latif LM, Kendall DA, Pardon MC. Corticosterone protects against memory impairments and reduced hippocampal BDNF levels induced by a chronic low dose of ethanol in C57BL/6J mice. Rom J Morphol Embryol. 2014;55(4):1303-16. PubMed PMID: 25611260. 3: Sturm M, Becker A, Schroeder A, Bilkei-Gorzo A, Zimmer A. Effect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J mice. Genes Brain Behav. 2015 Mar;14(3):292-300. doi: 10.1111/gbb.12208. Epub 2015 Mar 25. PubMed PMID: 25752475. 4: Claflin DI, Greenfield LR, Hennessy MB. Modest elevation of corticosterone in preweanling rats impairs subsequent trace eyeblink conditioning during the juvenile period. Behav Brain Res. 2014 Jan 1;258:19-26. doi: 10.1016/j.bbr.2013.10.008. Epub 2013 Oct 18. PubMed PMID: 24140564; PubMed Central PMCID: PMC3884574. 5: Llansola M, Ahabrach H, Errami M, Cabrera-Pastor A, Addaoudi K, Felipo V. Impaired release of corticosterone from adrenals contributes to impairment of circadian rhythms of activity in hyperammonemic rats. Arch Biochem Biophys. 2013 Aug 15;536(2):164-70. doi: 10.1016/j.abb.2013.01.009. Epub 2013 Feb 1. PubMed PMID: 23376587. 6: Maayan R, Hirsh L, Yadid G, Weizman A. Dehydroepiandrosterone Attenuates Cocaine-Seeking Behaviour Independently of Corticosterone Fluctuations. J Neuroendocrinol. 2015 Nov;27(11):819-26. doi: 10.1111/jne.12322. PubMed PMID: 26309224. 7: Kaplowitz ET, Savenkova M, Karatsoreos IN, Romeo RD. Somatic and Neuroendocrine Changes in Response to Chronic Corticosterone Exposure During Adolescence in Male and Female Rats. J Neuroendocrinol. 2016 Feb;28(2):12336. doi: 10.1111/jne.12336. PubMed PMID: 26568535. 8: Zhang H, Zhao Y, Wang Z. Chronic corticosterone exposure reduces hippocampal astrocyte structural plasticity and induces hippocampal atrophy in mice. Neurosci Lett. 2015 Apr 10;592:76-81. doi: 10.1016/j.neulet.2015.03.006. Epub 2015 Mar 4. PubMed PMID: 25748318. 9: Almasi B, Roulin A, Jenni L. Corticosterone shifts reproductive behaviour towards self-maintenance in the barn owl and is linked to melanin-based coloration in females. Horm Behav. 2013 Jun;64(1):161-71. doi: 10.1016/j.yhbeh.2013.03.001. Epub 2013 Apr 11. PubMed PMID: 23583559. 10: Thierry AM, Massemin S, Handrich Y, Raclot T. Elevated corticosterone levels and severe weather conditions decrease parental investment of incubating Adélie penguins. Horm Behav. 2013 Mar;63(3):475-83. doi: 10.1016/j.yhbeh.2012.12.011. Epub 2013 Jan 3. PubMed PMID: 23291423. 11: Takatsu-Coleman AL, Zanin KA, Patti CL, Zager A, Lopes-Silva LB, Longo BM, Tufik S, Andersen ML, Frussa-Filho R. Short-term sleep deprivation reinstates memory retrieval in mice: the role of corticosterone secretion. Psychoneuroendocrinology. 2013 Oct;38(10):1967-78. doi: 10.1016/j.psyneuen.2013.02.016. Epub 2013 Mar 30. PubMed PMID: 23545263. 12: Wu TC, Chen HT, Chang HY, Yang CY, Hsiao MC, Cheng ML, Chen JC. Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior. Psychoneuroendocrinology. 2013 Jun;38(6):871-83. doi: 10.1016/j.psyneuen.2012.09.011. Epub 2012 Oct 6. PubMed PMID: 23044404. 13: Shahbazi M, Jimenez P, Martinez LA, Carruth LL. Effects of housing condition and early corticosterone treatment on learned features of song in adult male zebra finches. Horm Behav. 2014 Mar;65(3):226-37. doi: 10.1016/j.yhbeh.2014.01.010. Epub 2014 Feb 1. PubMed PMID: 24492024. 14: Kott JM, Mooney-Leber SM, Shoubah FA, Brummelte S. Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior, and affect neurogenesis levels in female rats. Neuroscience. 2016 Jan 15;312:201-14. doi: 10.1016/j.neuroscience.2015.11.006. Epub 2015 Nov 10. PubMed PMID: 26556064. 15: Reis FM, Albrechet-Souza L, Franci CR, Brandão ML. Risk assessment behaviors associated with corticosterone trigger the defense reaction to social isolation in rats: role of the anterior cingulate cortex. Stress. 2012 May;15(3):318-28. doi: 10.3109/10253890.2011.623740. Epub 2011 Oct 12. PubMed PMID: 21992055. 16: De Filippis B, Ricceri L, Fuso A, Laviola G. Neonatal exposure to low dose corticosterone persistently modulates hippocampal mineralocorticoid receptor expression and improves locomotor/exploratory behaviour in a mouse model of Rett syndrome. Neuropharmacology. 2013 May;68:174-83. doi: 10.1016/j.neuropharm.2012.05.048. Epub 2012 Jun 16. PubMed PMID: 22709945. 17: Donner NC, Montoya CD, Lukkes JL, Lowry CA. Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. Psychoneuroendocrinology. 2012 May;37(5):645-61. doi: 10.1016/j.psyneuen.2011.08.008. Epub 2011 Sep 15. PubMed PMID: 21924839; PubMed Central PMCID: PMC3249349. 18: Dehnhard N, Poisbleau M, Demongin L, Chastel O, van Noordwijk HJ, Quillfeldt P. Leucocyte profiles and corticosterone in chicks of southern rockhopper penguins. J Comp Physiol B. 2011 Jan;181(1):83-90. doi: 10.1007/s00360-010-0508-4. Epub 2010 Aug 19. PubMed PMID: 20721561. 19: Pinson SE, Parr CM, Wilson JL, Navara KJ. Acute corticosterone administration during meiotic segregation stimulates females to produce more male offspring. Physiol Biochem Zool. 2011 May-Jun;84(3):292-8. doi: 10.1086/659373. PubMed PMID: 21527820. 20: Salomon S, Bejar C, Schorer-Apelbaum D, Weinstock M. Corticosterone mediates some but not other behavioural changes induced by prenatal stress in rats. J Neuroendocrinol. 2011 Feb;23(2):118-28. doi: 10.1111/j.1365-2826.2010.02097.x. PubMed PMID: 21108672.

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