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MedKoo Cat#: 526033 | Name: TISCH

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TISCH is a potent and selective iodinated ligand for CNS D1 dopamine receptor.

Chemical Structure

TISCH
CAS#131615-52-6

Theoretical Analysis

MedKoo Cat#: 526033

Name: TISCH

CAS#: 131615-52-6

Chemical Formula: C17H17ClINO

Exact Mass: 413.0043

Molecular Weight: 413.68

Elemental Analysis: C, 49.36; H, 4.14; Cl, 8.57; I, 30.68; N, 3.39; O, 3.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TISCH
IUPAC/Chemical Name
(R)-8-Chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-1H-3-benzazepin-7-ol
InChi Key
DUTJKDUWCSYNLM-OAHLLOKOSA-N
InChi Code
InChI=1S/C17H17ClINO/c1-20-6-5-12-8-16(18)17(21)9-14(12)15(10-20)11-3-2-4-13(19)7-11/h2-4,7-9,15,21H,5-6,10H2,1H3/t15-/m1/s1
SMILES Code
OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC(I)=C3)C2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Smith CB, Phillips T, Smith TJ. Using the New ASCO Clinical Practice Guideline for Palliative Care Concurrent With Oncology Care Using the TEAM Approach. Am Soc Clin Oncol Educ Book. 2017;37:714-723. doi: 10.14694/EDBK_175474. PubMed PMID: 28561696. 2: Masuda K, Ono A, Aikata H, Kawaoka T, Nelson Hayes C, Teraoka Y, Daijo K, Nakamura-Inagaki Y, Morio K, Fujino H, Kan H, Uchida T, Masaki K, Kobayashi T, Nakahara T, Makokha GN, Zhang Y, Nagaoki Y, Miki D, Tsuge M, Hiramatsu A, Imamura M, Abe-Chayama H, Kawakami Y, Ochi H, Chayama K. Erratum to: Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy. J Gastroenterol. 2017 May 29. doi: 10.1007/s00535-017-1352-z. [Epub ahead of print] PubMed PMID: 28555325. 3: Germain D. Toward the identification and the targeting of key players of the mitochondrial unfolded protein response (UPR(mt)) in cancer. J Bioenerg Biomembr. 2017 May 29. doi: 10.1007/s10863-017-9716-x. [Epub ahead of print] PubMed PMID: 28555290. 4: Molotkov A, Mazot P, Brewer JR, Cinalli RM, Soriano P. Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency. Dev Cell. 2017 May 23. pii: S1534-5807(17)30386-6. doi: 10.1016/j.devcel.2017.05.004. [Epub ahead of print] PubMed PMID: 28552557. 5: de Galarreta MR, Lujambio A. Therapeutic editing of hepatocyte genome in vivo. J Hepatol. 2017 May 17. pii: S0168-8278(17)32048-2. doi: 10.1016/j.jhep.2017.05.012. [Epub ahead of print] Review. PubMed PMID: 28527665. 6: Patel V, Collazo Lorduy A, Stern A, Fahmy O, Pinotti R, Galsky MD, Gakis G. Survival after Metastasectomy for Metastatic Urothelial Carcinoma: A Systematic Review and Meta-Analysis. Bladder Cancer. 2017 Apr 27;3(2):121-132. doi: 10.3233/BLC-170108. PubMed PMID: 28516157; PubMed Central PMCID: PMC5409038. 7: Gnjatic S, Bronte V, Brunet LR, Butler MO, Disis ML, Galon J, Hakansson LG, Hanks BA, Karanikas V, Khleif SN, Kirkwood JM, Miller LD, Schendel DJ, Tanneau I, Wigginton JM, Butterfield LH. Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy. J Immunother Cancer. 2017 May 16;5:44. doi: 10.1186/s40425-017-0243-4. eCollection 2017. Review. PubMed PMID: 28515944; PubMed Central PMCID: PMC5432988. 8: Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A. CNS Macrophages Control Neurovascular Development via CD95L. Cell Rep. 2017 May 16;19(7):1378-1393. doi: 10.1016/j.celrep.2017.04.056. PubMed PMID: 28514658. 9: Chakraborty R, Hampton OA, Abhyankar H, Zinn DJ, Grimes A, Skull B, Eckstein O, Mahmood N, Wheeler DA, Lopez-Terrada D, Peters TL, Hicks JM, Elghetany T, Krance R, Poulikakos PI, Merad M, McClain KL, Allen CE, Parsons DW. Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma. Oncotarget. 2017 Apr 29. doi: 10.18632/oncotarget.17521. [Epub ahead of print] PubMed PMID: 28512266. 10: Dennis EL, Faskowitz J, Rashid F, Babikian T, Mink R, Babbitt C, Johnson J, Giza CC, Jahanshad N, Thompson PM, Asarnow RF. Diverging volumetric trajectories following pediatric traumatic brain injury. Neuroimage Clin. 2017 Mar 31;15:125-135. doi: 10.1016/j.nicl.2017.03.014. eCollection 2017. PubMed PMID: 28507895; PubMed Central PMCID: PMC5423316. 11: Higashi T, Friedman SL, Hoshida Y. Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev. 2017 May 12. pii: S0169-409X(17)30063-7. doi: 10.1016/j.addr.2017.05.007. [Epub ahead of print] PubMed PMID: 28506744. 12: Migliaccio AR, Uversky VN. Dissecting physical structure of calreticulin, an intrinsically disordered Ca(2+)-buffering chaperone from endoplasmic reticulum. J Biomol Struct Dyn. 2017 May 26:1-20. doi: 10.1080/07391102.2017.1330224. [Epub ahead of print] PubMed PMID: 28504081. 13: Tisch M. [Implantable Hearing Devices]. Laryngorhinootologie. 2017 Apr;96(S 01):S84-S102. doi: 10.1055/s-0042-118775. Epub 2017 May 12. German. PubMed PMID: 28499296. 14: Stappler E, Dattenböck C, Tisch D, Schmoll M. Analysis of Light- and Carbon-Specific Transcriptomes Implicates a Class of G-Protein-Coupled Receptors in Cellulose Sensing. mSphere. 2017 May 10;2(3). pii: e00089-17. doi: 10.1128/mSphere.00089-17. eCollection 2017 May-Jun. PubMed PMID: 28497120; PubMed Central PMCID: PMC5425790. 15: Tsao CK, Liaw B, He C, Galsky MD, Sfakianos J, Oh WK. Moving beyond vascular endothelial growth factor-targeted therapy in renal cell cancer: latest evidence and therapeutic implications. Ther Adv Med Oncol. 2017 Apr;9(4):287-298. doi: 10.1177/1758834016687261. Epub 2017 Feb 14. Review. PubMed PMID: 28491148; PubMed Central PMCID: PMC5405995. 16: Alimohammadian M, Majidi A, Yaseri M, Ahmadi B, Islami F, Derakhshan M, Delavari A, Amani M, Feyz-Sani A, Poustchi H, Pourshams A, Sadjadi AM, Khoshnia M, Qaravi S, Abnet CC, Dawsey S, Brennan P, Kamangar F, Boffetta P, Sadjadi A, Malekzadeh R. Multimorbidity as an important issue among women: results of a gender difference investigation in a large population-based cross-sectional study in West Asia. BMJ Open. 2017 May 9;7(5):e013548. doi: 10.1136/bmjopen-2016-013548. PubMed PMID: 28490550. 17: Necchi A, Raggi D, Giannatempo P, Sonpavde G, Galsky MD, Bellmunt J, Mariani L, Miceli R. From the Uncertainties to the Evidence: A Brief History of Immunotherapy as Salvage Therapy for Advanced Bladder Cancer Through a Meta-analysis. Clin Genitourin Cancer. 2017 Apr 13. pii: S1558-7673(17)30092-7. doi: 10.1016/j.clgc.2017.04.008. [Epub ahead of print] PubMed PMID: 28478885. 18: Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, Remark R, Sweeney R, Becker CD, Levine JH, Meinhof K, Chow A, Kim-Shulze S, Wolf A, Medaglia C, Li H, Rytlewski JA, Emerson RO, Solovyov A, Greenbaum BD, Sanders C, Vignali M, Beasley MB, Flores R, Gnjatic S, Pe'er D, Rahman A, Amit I, Merad M. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. Cell. 2017 May 4;169(4):750-765.e17. doi: 10.1016/j.cell.2017.04.014. PubMed PMID: 28475900. 19: Masuda K, Ono A, Aikata H, Kawaoka T, Nelson Hayes C, Teraoka Y, Daijo K, Nakamura-Inagaki Y, Morio K, Fujino H, Kan H, Uchida T, Masaki K, Kobayashi T, Nakahara T, Makokha GN, Zhang Y, Nagaoki Y, Miki D, Tsuge M, Hiramatsu A, Imamura M, Abe-Chayama H, Kawakami Y, Ochi H, Chayama K. Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy. J Gastroenterol. 2017 May 4. doi: 10.1007/s00535-017-1348-8. [Epub ahead of print] Erratum in: J Gastroenterol. 2017 May 29;:. PubMed PMID: 28474222. 20: Narloch JL, Farber SH, Sammons S, McSherry F, Herndon JE 2nd, Hoang JK, Yin FF, Sampson JH, Fecci PE, Blackwell KL, Kirkpatrick JP, Kim GJ. Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis. Neuro Oncol. 2017 May 3. doi: 10.1093/neuonc/nox090. [Epub ahead of print] PubMed PMID: 28472527.