MedKoo Cat#: 526011 | Name: rac-CCT-250863
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

rac-CCT-250863 is a potent Nek2 inhibitor. exhibiting selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.

Chemical Structure

rac-CCT-250863
rac-CCT-250863
CAS#1364269-06-6

Theoretical Analysis

MedKoo Cat#: 526011

Name: rac-CCT-250863

CAS#: 1364269-06-6

Chemical Formula: C24H25F3N4O2S

Exact Mass: 490.1650

Molecular Weight: 490.55

Elemental Analysis: C, 58.76; H, 5.14; F, 11.62; N, 11.42; O, 6.52; S, 6.54

Price and Availability

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5mg USD 750.00
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Related CAS #
No Data
Synonym
rac-CCT-250863
IUPAC/Chemical Name
4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide
InChi Key
LLEOOSLUHRQCHZ-SREVYHEPSA-N
InChi Code
InChI=1S/C24H25F3N4O2S/c1-14(6-7-24(25,26)27)33-20-10-16(4-5-18(20)23(29)32)19-9-17(11-30-22(19)28)21-8-15(13-34-21)12-31(2)3/h4-11,13-14H,12H2,1-3H3,(H2,28,30)(H2,29,32)/b7-6-
SMILES Code
O=C(N)C1=CC=C(C2=CC(C3=CC(CN(C)C)=CS3)=CN=C2N)C=C1OC(C)/C=C\C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 490.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Jeong, A. L., Ka, H. I., Han, S., Lee, S., Lee, E. W., Soh, S. J., ... & Yang, Y. (2018). Oncoprotein CIP 2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism. EMBO reports, 19(5), e45144. Bhuiyan, A. I., Choi, A. H., Ghoshal, S., Adiele, U. A., Dana, D., Choi, J. Y., ... & Pathak, S. K. (2023). Identification of a novel spirocyclic Nek2 inhibitor using high throughput virtual screening. Bioorganic & medicinal chemistry letters, 88, 129288. DeVaul, N., Koloustroubis, K., Wang, R., & Sperry, A. O. (2017). A novel interaction between kinase activities in regulation of cilia formation. BMC cell biology, 18, 1-18. Bisteau, X., Lee, J., Srinivas, V., Lee, J. H., Niska-Blakie, J., Tan, G., ... & Kaldis, P. (2020). The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis. Oncogene, 39(44), 6816-6840.