ZK110841 | CAS#105595-17-3 | Prostaglandin DP-receptor Agonist

MedKoo Cat#: 532998 | Name: ZK110841

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZK110841 is an agonist of prostaglandin DP-receptors on human platelet. ZK110841 elevated the adenosine 3':5'-cyclic monophosphate (cyclic AMP) level in EBTr cells dose-dependently, being more than 100 fold over the basal level at 1 microM.

Chemical Structure

ZK110841

CAS# 105595-17-3

Theoretical Analysis

MedKoo Cat#: 532998

Name: ZK110841

CAS#: 105595-17-3

Chemical Formula: C21H33ClO4

Exact Mass: 384.2067

Molecular Weight: 384.94

Elemental Analysis: C, 65.52; H, 8.64; Cl, 9.21; O, 16.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ZK110841; ZK 110841; ZK-110841.

IUPAC/Chemical Name

(Z)-7-[(2R,3R,5R)-5-chloro-2-[(E,3S)-3-cyclohexyl-3-hydroxyprop-1-enyl]-3-hydroxycyclopentyl]hept-5-enoic acid

InChi Key

ZOQXTNLUBHPZOZ-GZFHOOQWSA-N

InChi Code

InChI=1S/C21H33ClO4/c22-18-14-20(24)17(12-13-19(23)15-8-4-3-5-9-15)16(18)10-6-1-2-7-11-21(25)26/h1,6,12-13,15-20,23-24H,2-5,7-11,14H2,(H,25,26)/b6-1-,13-12+/t16?,17-,18-,19-,20-/m1/s1

SMILES Code

O=C(O)CCC/C=C\CC1[C@@H](/C=C/[C@H](C2CCCCC2)O)[C@H](O)C[C@H]1Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 384.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ito S, Okuda E, Sugama K, Negishi M, Hayaishi O. Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. Br J Pharmacol. 1990 Jan;99(1):13-4. PubMed PMID: 2158830; PubMed Central PMCID: PMC1917504.