MedKoo Cat#: 526005 | Name: KRP-199

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KRP-199 is a highly potent and selective antagonist for the AMPA receptors, exhibiting good neuroprotective effects in vivo.

Chemical Structure

KRP-199
KRP-199
CAS#221164-28-9

Theoretical Analysis

MedKoo Cat#: 526005

Name: KRP-199

CAS#: 221164-28-9

Chemical Formula: C22H14F3N5O7

Exact Mass: 517.0845

Molecular Weight: 517.38

Elemental Analysis: C, 51.07; H, 2.73; F, 11.02; N, 13.54; O, 21.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
KRP-199
IUPAC/Chemical Name
7-[4-[[[[(4-Carboxyphenyl)amino]carbonyl]oxy]methyl]-1H-imidazol-1-yl]-3,4-dihydro-3-oxo-6-(trifluoromethyl)-2-quinoxalinecarboxylic acid
InChi Key
AEFZZVQZPBFFPN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H14F3N5O7/c23-22(24,25)13-5-14-15(28-17(20(34)35)18(31)29-14)6-16(13)30-7-12(26-9-30)8-37-21(36)27-11-3-1-10(2-4-11)19(32)33/h1-7,9H,8H2,(H,27,36)(H,29,31)(H,32,33)(H,34,35)
SMILES Code
O=C(C1=NC2=C(C=C(C(F)(F)F)C(N3C=C(COC(NC4=CC=C(C(O)=O)C=C4)=O)N=C3)=C2)NC1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 517.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takano Y, Shiga F, Asano J, Hori W, Fukuchi K, Anraku T, Uno T. Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties. Bioorg Med Chem. 2006 Feb 1;14(3):776-92. Epub 2005 Oct 7. PubMed PMID: 16214358. 2: Takano Y, Shiga F, Asano J, Hori W, Anraku T, Uno T. Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11. PubMed PMID: 15380209.