VU6004256 | CAS#2011034-33-4 | M1 Positive Allosteric Modulator

MedKoo Cat#: 526000 | Name: VU6004256

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU6004256 is a novel selective muscarinic receptor M1 positive allosteric modulator (PAM).

Chemical Structure

VU6004256

CAS#2011034-33-4

Theoretical Analysis

MedKoo Cat#: 526000

Name: VU6004256

CAS#: 2011034-33-4

Chemical Formula: C25H25F2N5O2

Exact Mass: 465.1976

Molecular Weight: 465.50

Elemental Analysis: C, 64.51; H, 5.41; F, 8.16; N, 15.04; O, 6.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

VU6004256, VU-6004256, VU 6004256

IUPAC/Chemical Name

4,6-Difluoro-1-[6-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-ylmethyl]-1H-indole-3-carboxylic acid (2(R)-hydroxy-cyclohex-1(R)-yl)-amide

InChi Key

ZZMZFDCJQBUOOI-GMAHTHKFSA-N

InChi Code

InChI=1S/C25H25F2N5O2/c1-31-13-16(11-29-31)20-7-6-15(10-28-20)12-32-14-18(24-19(27)8-17(26)9-22(24)32)25(34)30-21-4-2-3-5-23(21)33/h6-11,13-14,21,23,33H,2-5,12H2,1H3,(H,30,34)/t21-,23-/m0/s1

SMILES Code

O[C@@H]1[C@@H](NC(C2=CN(CC3=CC=C(C4=CN(C)N=C4)N=C3)C5=CC(F)=CC(F)=C52)=O)CCCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 465.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK. Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M(1) PAM VU6004256. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716. doi: 10.1021/acschemneuro.6b00230. Epub 2016 Oct 5. PubMed PMID: 27617634; PubMed Central PMCID: PMC5231396.