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MedKoo Cat#: 525972 | Name: PBI-51
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PBI-51 is a competitive Inhibitor of Abscisic Acid-Regulated Gene Expression. PBI-51 displayed a reversible antagonistic effect with ABA, shifting the typical ABA dose-response curve by a factor of 4 to 5.

Chemical Structure

PBI-51
PBI-51
CAS#130694-74-5

Theoretical Analysis

MedKoo Cat#: 525972

Name: PBI-51

CAS#: 130694-74-5

Chemical Formula: C15H22O3

Exact Mass: 250.1569

Molecular Weight: 250.34

Elemental Analysis: C, 71.97; H, 8.86; O, 19.17

Price and Availability

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2.5mg USD 700.00
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Related CAS #
No Data
Synonym
PBI-51
IUPAC/Chemical Name
(4S,5R)-4-hydroxy-4-((Z)-5-hydroxy-3-methylpent-3-en-1-ynyl)-3,3,5-trimethylcyclohexanone
InChi Key
WORLVFQFRWYCAV-CWJQNXGWSA-N
InChi Code
InChI=1S/C15H22O3/c1-11(6-8-16)5-7-15(18)12(2)9-13(17)10-14(15,3)4/h6,12,16,18H,8-10H2,1-4H3/b11-6-/t12-,15+/m1/s1
SMILES Code
O=C1CC(C)(C)[C@@](C#C/C(C)=C\CO)(O)[C@H](C)C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PBI-51 is a competitive Inhibitor of Abscisic Acid-Regulated Gene Expression.
In vitro activity:
PBI-51 displayed a reversible antagonistic effect with ABA, shifting the typical ABA dose-response curve by a factor of 4 to 5. This antagonism was noted for the expression of two ABA-sensitive genes, napin and oleosin. To test whether this antagonism was at the level of ABA recognition or uptake, ABA uptake was monitored in the presence of PBI-51 or PBI-63. Neither compound decreased ABA uptake. Treatments with either PBI-51 or PBI-63 showed an effect on endogenous ABA pools by permitting increases of 5- to 7-fold. Reference: Plant Physiol. 1993 Feb;101(2):469-476. https://pubmed.ncbi.nlm.nih.gov/12231700/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 250.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Yamazaki D, Yoshida S, Asami T, Kuchitsu K. Visualization of abscisic acid-perception sites on the plasma membrane of stomatal guard cells. Plant J. 2003 Jul;35(1):129-39. doi: 10.1046/j.1365-313x.2003.01782.x. PMID: 12834408. 2. Wilen RW, Hays DB, Mandel RM, Abrams SR, Moloney MM. Competitive Inhibition of Abscisic Acid-Regulated Gene Expression by Stereoisomeric Acetylenic Analogs of Abscisic Acid. Plant Physiol. 1993 Feb;101(2):469-476. doi: 10.1104/pp.101.2.469. PMID: 12231700; PMCID: PMC160593.
In vitro protocol:
1. Yamazaki D, Yoshida S, Asami T, Kuchitsu K. Visualization of abscisic acid-perception sites on the plasma membrane of stomatal guard cells. Plant J. 2003 Jul;35(1):129-39. doi: 10.1046/j.1365-313x.2003.01782.x. PMID: 12834408. 2. Wilen RW, Hays DB, Mandel RM, Abrams SR, Moloney MM. Competitive Inhibition of Abscisic Acid-Regulated Gene Expression by Stereoisomeric Acetylenic Analogs of Abscisic Acid. Plant Physiol. 1993 Feb;101(2):469-476. doi: 10.1104/pp.101.2.469. PMID: 12231700; PMCID: PMC160593.
In vivo protocol:
TBD
1: Yamazaki D, Yoshida S, Asami T, Kuchitsu K. Visualization of abscisic acid-perception sites on the plasma membrane of stomatal guard cells. Plant J. 2003 Jul;35(1):129-39. PubMed PMID: 12834408. 2: Wilen RW, Hays DB, Mandel RM, Abrams SR, Moloney MM. Competitive Inhibition of Abscisic Acid-Regulated Gene Expression by Stereoisomeric Acetylenic Analogs of Abscisic Acid. Plant Physiol. 1993 Feb;101(2):469-476. PubMed PMID: 12231700; PubMed Central PMCID: PMC160593.

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UNC5114

UNC5114