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MedKoo Cat#: 525938 | Name: MDK0734

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK0734, also known as Cathepsin B Inhinitor-42, is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities. MDK0734 has CAS#1366240-73-4. The last 4 digit is used for naming.

Chemical Structure

MDK0734
MDK0734
CAS#1366240-73-4

Theoretical Analysis

MedKoo Cat#: 525938

Name: MDK0734

CAS#: 1366240-73-4

Chemical Formula: C15H17N3O2

Exact Mass: 271.1321

Molecular Weight: 271.32

Elemental Analysis: C, 66.40; H, 6.32; N, 15.49; O, 11.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Cathepsin B Inhinitor-42
IUPAC/Chemical Name
8-(4-Methylpiperidin-1-yl)-5-nitroquinoline
InChi Key
ABDSNJJYMMKJBF-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H17N3O2/c1-11-6-9-17(10-7-11)14-5-4-13(18(19)20)12-3-2-8-16-15(12)14/h2-5,8,11H,6-7,9-10H2,1H3
SMILES Code
O=[N+](C1=C2C=CC=NC2=C(N3CCC(C)CC3)C=C1)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 271.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Design, synthesis, and structure-activity relationship study of epoxysuccinyl-peptide derivatives as cathepsin B inhibitors. Biol Pharm Bull. 2017 May 13. doi: 10.1248/bpb.b17-00075. [Epub ahead of print] PubMed PMID: 28502922. 5: Zhu YM, Gao X, Ni Y, Li W, Kent TA, Qiao SG, Wang C, Xu XX, Zhang HL. Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia-reperfusion brain injury. Neuroscience. 2017 May 10. pii: S0306-4522(17)30320-2. doi: 10.1016/j.neuroscience.2017.05.004. [Epub ahead of print] PubMed PMID: 28501505. 6: Lysenko LA, Kantserova NP, Kaivarainen EI, Krupnova MY, Nemova NN. Skeletal muscle protease activities in the early growth and development of wild Atlantic salmon (Salmo salar L.). Comp Biochem Physiol B Biochem Mol Biol. 2017 May 10. pii: S1096-4959(17)30065-9. doi: 10.1016/j.cbpb.2017.05.001. [Epub ahead of print] PubMed PMID: 28499850. 7: Mitrović A, Pečar Fonović U, Kos J. Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells. Eur J Cell Biol. 2017 Apr 25. pii: S0171-9335(16)30277-1. doi: 10.1016/j.ejcb.2017.04.003. [Epub ahead of print] PubMed PMID: 28495172. 8: Venkatesan R, Park YU, Ji E, Yeo EJ, Kim SY. Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer's disease. Cell Death Discov. 2017 Apr 24;3:17007. doi: 10.1038/cddiscovery.2017.7. eCollection 2017. PubMed PMID: 28487766; PubMed Central PMCID: PMC5402539. 9: Wiesak T, Wasielak M, Złotkowska A, Milewski R. Effect of vitrification on the zona pellucida hardening and follistatin and cathepsin B genes expression and developmental competence of in vitro matured bovine oocytes. Cryobiology. 2017 May 6. pii: S0011-2240(17)30072-X. doi: 10.1016/j.cryobiol.2017.05.001. [Epub ahead of print] PubMed PMID: 28487134. 10: Wang Y, Wen Y, Wang S, Ehsan M, Yan R, Song X, Xu L, Li X. Modulation of goat monocyte function by HCcyst-2, a secreted cystatin from Haemonchus contortus. Oncotarget. 2017 Apr 21. doi: 10.18632/oncotarget.17308. [Epub ahead of print] PubMed PMID: 28484087. 11: Zhang F, Chen D, Wang Y, Zhang L, Dong W, Dai J, Jin C, Dong X, Sun Y, Zhao H, Fan K, Liu H, Chen B, Zou H, Li W. Lysosome-dependent necrosis specifically evoked in cancer cells by gold nanorods. Nanomedicine (Lond). 2017 May 8. doi: 10.2217/nnm-2017-0126. [Epub ahead of print] PubMed PMID: 28478730. 12: Nagakannan P, Eftekharpour E. Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells. Free Radic Biol Med. 2017 May 3;108:819-831. doi: 10.1016/j.freeradbiomed.2017.05.005. [Epub ahead of print] PubMed PMID: 28478025. 13: Jiang WD, Wu P, Tang RJ, Liu Y, Kuang SY, Jiang J, Tang L, Tang WN, Zhang YA, Zhou XQ, Feng L. Nutritive values, flavor amino acids, healthcare fatty acids and flesh quality improved by manganese referring to up-regulating the antioxidant capacity and signaling molecules TOR and Nrf2 in the muscle of fish. Food Res Int. 2016 Nov;89(Pt 1):670-678. doi: 10.1016/j.foodres.2016.09.020. Epub 2016 Sep 21. PubMed PMID: 28460965. 14: Ngcungcu T, Oti M, Sitek JC, Haukanes BI, Linghu B, Bruccoleri R, Stokowy T, Oakeley EJ, Yang F, Zhu J, Sultan M, Schalkwijk J, van Vlijmen-Willems IMJJ, von der Lippe C, Brunner HG, Ersland KM, Grayson W, Buechmann-Moller S, Sundnes O, Nirmala N, Morgan TM, van Bokhoven H, Steen VM, Hull PR, Szustakowski J, Staedtler F, Zhou H, Fiskerstrand T, Ramsay M. Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families. Am J Hum Genet. 2017 May 4;100(5):737-750. doi: 10.1016/j.ajhg.2017.03.012. Epub 2017 Apr 27. PubMed PMID: 28457472; PubMed Central PMCID: PMC5420352. 15: Giraldo AMV, Öllinger K, Loitto V. Microscopic Analysis of Lysosomal Membrane Permeabilization. Methods Mol Biol. 2017;1594:73-92. doi: 10.1007/978-1-4939-6934-0_5. PubMed PMID: 28456977. 16: Abdulla MH, Valli-Mohammed MA, Al-Khayal K, Al Shkieh A, Zubaidi A, Ahmad R, Al-Saleh K, Al-Obeed O, McKerrow J. Cathepsin B expression in colorectal cancer in a Middle East population: Potential value as a tumor biomarker for late disease stages. Oncol Rep. 2017 Jun;37(6):3175-3180. doi: 10.3892/or.2017.5576. Epub 2017 Apr 18. PubMed PMID: 28440429; PubMed Central PMCID: PMC5442396. 17: Yan Y, Zhou K, Wang L, Wang F, Chen X, Fan Q. Clinical significance of serum cathepsin B and cystatin C levels and their ratio in the prognosis of patients with esophageal cancer. Onco Targets Ther. 2017 Apr 3;10:1947-1954. doi: 10.2147/OTT.S123042. eCollection 2017. PubMed PMID: 28435284; PubMed Central PMCID: PMC5388217. 18: Li SH, Li R, Zhong HX, Chen XH, Liu AP, Yang J, Hu Q, Ke QQ, Li ML. Immunolocalization of Jian Carp (Cyprinus Carpio Var. Jian) Cathepsin B: Cloning, Expression, Characterization, and Antibody Preparation. J Food Sci. 2017 May;82(5):1092-1100. doi: 10.1111/1750-3841.13708. Epub 2017 Apr 20. PubMed PMID: 28425565. 19: Breznik B, Motaln H, Vittori M, Rotter A, Lah Turnšek T. Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines. Oncotarget. 2017 Apr 11;8(15):25482-25499. doi: 10.18632/oncotarget.16041. PubMed PMID: 28424417; PubMed Central PMCID: PMC5421945. 20: Su Y, Wu J, He J, Liu X, Chen X, Ding Y, Zhang C, Chen W, Wang Y, Gao R. High insulin impaired ovarian function in early pregnant mice and the role of autophagy in this process. Endocr J. 2017 Apr 18. doi: 10.1507/endocrj.EJ16-0494. 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