NCL00017509 | Nek2 inhibitor | CAS#1507367-00-1

MedKoo Cat#: 525903 | Name: NCL00017509

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NCL00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor.

Chemical Structure

NCL00017509

CAS#1507367-00-1

Theoretical Analysis

MedKoo Cat#: 525903

Name: NCL00017509

CAS#: 1507367-00-1

Chemical Formula: C15H12N6O

Exact Mass: 292.1073

Molecular Weight: 292.30

Elemental Analysis: C, 61.64; H, 4.14; N, 28.75; O, 5.47

Price and Availability

Size	Price	Availability
25mg	USD 750.00	2 Weeks
50mg	USD 1,250.00	2 Weeks
100mg	USD 1,950.00	2 Weeks
1g	USD 4,950.00	2 Weeks

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Related CAS #

No Data

Synonym

NCL00017509, NCL 00017509, NCL-00017509; Nek2-IN-5

IUPAC/Chemical Name

3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide

InChi Key

CJQGLUJHMXCLQY-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H12N6O/c1-2-11-13-14(18-8-17-13)21-15(20-11)19-10-5-3-4-9(6-10)7-12(16)22/h1,3-6,8H,7H2,(H2,16,22)(H2,17,18,19,20,21)

SMILES Code

O=C(N)CC1=CC=CC(NC2=NC(C#C)=C3N=CNC3=N2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NCL00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	29.2	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 292.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

Lebraud H, Coxon CR, Archard VS, Bawn CM, Carbain B, Matheson CJ, Turner DM, Cano C, Griffin RJ, Hardcastle IR, Baisch U, Harrington RW, Golding BT. Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org Biomol Chem. 2014 Jan 7;12(1):141-8. doi: 10.1039/c3ob41806e. Epub 2013 Nov 8. PMID: 24213855.