Synonym
WIN 62,577; WIN62,577; WIN-62,577.
IUPAC/Chemical Name
(1R,3aS,3bR,15aR,15bS,17aS)-1-ethynyl-15a,17a-dimethyl-2,3,3a,3b,4,5,15,15a,15b,16,17,17a-dodecahydro-1H-benzo[4,5]imidazo[2,1-b]cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-ol
InChi Key
YBCYJDNOPAFFOW-XOAARHKISA-N
InChi Code
InChI=1S/C29H31N3O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24/h1,5-8,15,17,20-22,33H,9-14,16H2,2-3H3/t20-,21+,22+,27+,28+,29+/m1/s1
SMILES Code
O[C@@]1(C#C)CC[C@@]2([H])[C@]3([H])CCC4=CC5=NC6=NC7=CC=CC=C7N6C=C5C[C@]4(C)[C@@]3([H])CC[C@@]21C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
437.59
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schober DA, Croy CH, Xiao H, Christopoulos A, Felder CC. Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites. Mol Pharmacol. 2014 Jul;86(1):116-23. doi: 10.1124/mol.114.091785. Epub 2014 May 7. PubMed PMID: 24807966.
2: Lanzafame AA, Sexton PM, Christopoulos A. Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors. Mol Pharmacol. 2006 Aug;70(2):736-46. Epub 2006 May 18. PubMed PMID: 16709648.
3: Lazareno S, Popham A, Birdsall NJ. Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. Mol Pharmacol. 2002 Dec;62(6):1492-505. PubMed PMID: 12435818.
4: Duvilanski BH, Pisera D, Seilicovich A, del Carmen Díaz M, Lasaga M, Isovich E, Velardez MO. Interaction between substance P and TRH in the control of prolactin release. J Endocrinol. 2000 Aug;166(2):373-80. PubMed PMID: 10927626.
5: Seguin L, Le Marouille-Girardon S, Millan MJ. Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: a comparison to other classes of antinociceptive agent. Pain. 1995 May;61(2):325-43. PubMed PMID: 7659444.
6: Isovich E, del Carmen Díaz M, Lasaga M, Pisera D, Zambruno C, Theas MS, Seilicovich A, Duvilanski BH. Involvement of hypothalamic substance P in the effect of prolactin on dopamine release. Neuroreport. 1994 Sep 8;5(14):1752-4. PubMed PMID: 7530063.
