MedKoo Cat#: 532953 | Name: VUF5574
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VUF5574 is a potent and selective histamine H4 receptor (H4R) agonist, a G protein-coupled receptor involved in modulating immune responses and inflammation. By activating H4R, VUF5574 enhances histamine-driven chemotaxis and cytokine release, making it a valuable tool for studying H4R-mediated signaling pathways in immunology.

Chemical Structure

VUF5574
VUF5574
CAS#280570-45-8

Theoretical Analysis

MedKoo Cat#: 532953

Name: VUF5574

CAS#: 280570-45-8

Chemical Formula: C21H17N5O2

Exact Mass: 371.1382

Molecular Weight: 371.40

Elemental Analysis: C, 67.91; H, 4.61; N, 18.86; O, 8.62

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 550.00 2 Weeks
10mg USD 700.00 2 Weeks
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Related CAS #
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Synonym
VUF5574, VUF 5574, VUF-5574
IUPAC/Chemical Name
3-(2-methoxyphenyl)-1-(2-pyridin-3-ylquinazolin-4-yl)urea
InChi Key
YRAFEJSZTVWUMD-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27)
SMILES Code
O=C(NC1=CC=CC=C1OC)NC2=C3C=CC=CC3=NC(C4=CC=CN=C4)=N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 371.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456. PMID: 11121831. 2. van Muijlwijk-Koezen et al (2000) Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J.Med.Chem. 43 2227. PMID: 10841801.