VU0155041 | CAS# 1093757-42-6 | mGlu4 Receptor PAM Modulator

MedKoo Cat#: 532896 | Name: VU0155041

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC₅₀ = 798 and 693 nM at human and rat mGlu4 receptors respectively). VU0155041 is active in in vivo models of Parkinson's disease.

Chemical Structure

VU0155041

CAS# 1093757-42-6

Theoretical Analysis

MedKoo Cat#: 532896

Name: VU0155041

CAS#: 1093757-42-6

Chemical Formula: C14H15Cl2NO3

Exact Mass: 315.0429

Molecular Weight: 316.18

Elemental Analysis: C, 53.18; H, 4.78; Cl, 22.42; N, 4.43; O, 15.18

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00
20mg	USD 550.00

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Related CAS #

1093757-42-6 (free) 1259372-69-4 (sodium salt)

Synonym

VU0155041, VU 0155041, VU-0155041

IUPAC/Chemical Name

cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid

InChi Key

VSMUYYFJVFSVCA-NWDGAFQWSA-N

InChi Code

InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)/t11-,12+/m0/s1

SMILES Code

O=C([C@H]1[C@@H](C(NC2=CC(Cl)=CC(Cl)=C2)=O)CCCC1)O

Appearance

White to off-white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 316.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ebrahimi Z, Gholipour P, Mohammadkhani R, Ghahremani R, Sarihi A, Komaki A, Salehi I, Karimi SA. Effect of intrahippocampal microinjection of VU0155041, a positive allosteric modulator of mGluR4, on long term potentiation in a valproic acid-induced autistic male rat model. IBRO Neurosci Rep. 2024 May 22;16:629-634. doi: 10.1016/j.ibneur.2024.05.005. PMID: 38832089; PMCID: PMC11144792. 2: Le Merrer J, Detraux B, Gandía J, De Groote A, Fonteneau M, de Kerchove d'Exaerde A, Becker JAJ. Balance Between Projecting Neuronal Populations of the Nucleus Accumbens Controls Social Behavior in Mice. Biol Psychiatry. 2024 Jan 15;95(2):123-135. doi: 10.1016/j.biopsych.2023.05.008. Epub 2023 May 18. PMID: 37207936. 3: Martín R, Suárez-Pinilla AS, García-Font N, Laguna-Luque ML, López-Ramos JC, Oset-Gasque MJ, Gruart A, Delgado-García JM, Torres M, Sánchez-Prieto J. The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome. Mol Autism. 2023 Apr 7;14(1):14. doi: 10.1186/s13229-023-00547-4. PMID: 37029391; PMCID: PMC10082511. 4: Ebrahimi Z, Kahvandi N, Shahriari E, Komaki A, Karimi SA, Naderishahab M, Sharifi M, Sarihi A. VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Brain Res Bull. 2023 Jun 1;197:57-64. doi: 10.1016/j.brainresbull.2023.03.012. Epub 2023 Mar 30. PMID: 36997034. 5: Zhang Z, Wang L, Liu Y, Luan Y, Zhu K, Tian Y, Liu Y, Zheng X. Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway. Brain Res. 2021 Sep 15;1767:147561. doi: 10.1016/j.brainres.2021.147561. Epub 2021 Jun 13. PMID: 34133989. 6: Ebrahimi Z, Kahvandi N, Komaki A, Karimi SA, Naderishahab M, Sarihi A. The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats. BMC Neurosci. 2021 Mar 21;22(1):17. doi: 10.1186/s12868-021-00627-2. PMID: 33743609; PMCID: PMC7981834. 7: Becker JAJ, Pellissier LP, Corde Y, Laboute T, Léauté A, Gandía J, Le Merrer J. Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice. Neuropsychopharmacology. 2021 Jun;46(7):1373-1385. doi: 10.1038/s41386-020-00927-x. Epub 2020 Dec 21. PMID: 33349673; PMCID: PMC8136479. 8: Zhang Z, Liu Y, Luan Y, Zhu K, Hu B, Ma B, Chen L, Liu X, Lu H, Chen X, Liu Y, Zheng X. Activation of Type 4 Metabotropic Glutamate Receptor Regulates Proliferation and Neuronal Differentiation in a Cultured Rat Retinal Progenitor Cell Through the Suppression of the cAMP/PTEN/AKT Pathway. Front Mol Neurosci. 2020 Aug 20;13:141. doi: 10.3389/fnmol.2020.00141. PMID: 32973444; PMCID: PMC7469868. 9: Abulwerdi G, Stoica BA, Loane DJ, Faden AI. Putative mGluR4 positive allosteric modulators activate Gi-independent anti-inflammatory mechanisms in microglia. Neurochem Int. 2020 Sep;138:104770. doi: 10.1016/j.neuint.2020.104770. Epub 2020 May 23. PMID: 32454165; PMCID: PMC7392812. 10: Fulton MG, Loch MT, Cuoco CA, Rodriguez AL, Days E, Vinson PN, Kozek KA, Weaver CD, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators. Lett Drug Des Discov. 2019 Dec;16(12):1387-1394. doi: 10.2174/1570180815666181017131349. PMID: 32201485; PMCID: PMC7059629. 11: Zhang Z, Zheng X, Liu Y, Luan Y, Wang L, Zhao L, Zhang J, Tian Y, Lu H, Chen X, Liu Y. Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression. J Neurochem. 2021 Feb;156(4):465-480. doi: 10.1111/jnc.14984. Epub 2020 Mar 12. PMID: 32052426. 12: Zhang Z, Liu Y, Wang K, Zhu K, Zheng X, Wang L, Luan Y, Wang X, Lu H, Wu K, Chen X, He D, Liu Y. Activation of type 4 metabotropic glutamate receptor promotes cell apoptosis and inhibits proliferation in bladder cancer. J Cell Physiol. 2019 Mar;234(3):2741-2755. doi: 10.1002/jcp.27089. Epub 2018 Aug 26. PMID: 30145816. 13: Zhang Z, Zheng X, Luan Y, Liu Y, Li X, Liu C, Lu H, Chen X, Liu Y. Activity of Metabotropic Glutamate Receptor 4 Suppresses Proliferation and Promotes Apoptosis With Inhibition of Gli-1 in Human Glioblastoma Cells. Front Neurosci. 2018 May 15;12:320. doi: 10.3389/fnins.2018.00320. PMID: 29867331; PMCID: PMC5962807. 14: Domin H, Przykaza Ł, Jantas D, Kozniewska E, Boguszewski PM, Śmiałowska M. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94. doi: 10.1016/j.neuropharm.2015.11.025. Epub 2015 Dec 2. PMID: 26647070. 15: Li TJ, Huang YH, Chen X, Zhou Z, Luo SW, Feng DD, Han JZ, Luo ZQ. [Metabotropic glutamate receptor 8 activation promotes the apoptosis of lung carcinoma A549 cells in vitro]. Sheng Li Xue Bao. 2015 Oct 25;67(5):513-20. Chinese. PMID: 26490069. 16: Zhang Z, Ma W, Wang L, Gong H, Tian Y, Zhang J, Liu J, Lu H, Chen X, Liu Y. Activation of Type 4 Metabotropic Glutamate Receptor Attenuates Oxidative Stress-Induced Death of Neural Stem Cells with Inhibition of JNK and p38 MAPK Signaling. Stem Cells Dev. 2015 Nov 15;24(22):2709-22. doi: 10.1089/scd.2015.0067. Epub 2015 Sep 1. PMID: 26176363; PMCID: PMC4652160. 17: Rovira X, Malhaire F, Scholler P, Rodrigo J, Gonzalez-Bulnes P, Llebaria A, Pin JP, Giraldo J, Goudet C. Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors. FASEB J. 2015 Jan;29(1):116-30. doi: 10.1096/fj.14-257287. Epub 2014 Oct 23. PMID: 25342125. 18: Rovira X, Harrak Y, Trapero A, González-Bulnes P, Malhaire F, Pin JP, Goudet C, Giraldo J, Llebaria A. Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor. ChemMedChem. 2014 Dec;9(12):2685-98. doi: 10.1002/cmdc.201402190. Epub 2014 Sep 5. PMID: 25196639. 19: Rossi F, Marabese I, De Chiaro M, Boccella S, Luongo L, Guida F, De Gregorio D, Giordano C, de Novellis V, Palazzo E, Maione S. Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. J Neurophysiol. 2014 Jun 1;111(11):2196-209. doi: 10.1152/jn.00212.2013. Epub 2013 Dec 4. PMID: 24304862. 20: Klakotskaia D, Ramsey AK, Fowler SW, Serfozo P, Simonyi A, Schachtman TR. Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning. Behav Brain Res. 2013 Sep 15;253:9-16. doi: 10.1016/j.bbr.2013.06.032. Epub 2013 Jul 1. PMID: 23827202.