XIE18-6 | CAS#1286862-52-9 | INK4C Inhibitor

MedKoo Cat#: 525778 | Name: XIE18-6

Description:

WARNING: This product is for research use only, not for human or veterinary use.

XIE18-6 is a novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein and promoting human and murine hematopoietic stem cell ex vivo expansion.

Chemical Structure

XIE18-6

CAS#1286862-52-9

Theoretical Analysis

MedKoo Cat#: 525778

Name: XIE18-6

CAS#: 1286862-52-9

Chemical Formula: C18H15NO6S

Exact Mass: 373.0620

Molecular Weight: 373.38

Elemental Analysis: C, 57.90; H, 4.05; N, 3.75; O, 25.71; S, 8.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

XIE18-6, XIE18 6, XIE186

IUPAC/Chemical Name

4-Acetylamino-benzenesulfonic acid 4-methyl-2-oxo-2H-chromen-7-yl ester

InChi Key

LOMKFWDFEIQKOS-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15NO6S/c1-11-9-18(21)24-17-10-14(5-8-16(11)17)25-26(22,23)15-6-3-13(4-7-15)19-12(2)20/h3-10H,1-2H3,(H,19,20)

SMILES Code

O=S(C1=CC=C(NC(C)=O)C=C1)(OC2=CC(O3)=C(C=C2)C(C)=CC3=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 373.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xie XQ, Yang P, Zhang Y, Zhang P, Wang L, Ding Y, Yang M, Tong Q, Cheng H, Ji Q, McGuire T, Yuan W, Cheng T, Gao Y. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115. doi: 10.1038/srep18115. PubMed PMID: 26681454; PubMed Central PMCID: PMC4683533.