MedKoo Cat#: 532885 | Name: VRT-325

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VRT-325 is a CFTR-F508delt corrector which modifies the channel function. The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation.

Chemical Structure

VRT-325
VRT-325
CAS#815592-21-3

Theoretical Analysis

MedKoo Cat#: 532885

Name: VRT-325

CAS#: 815592-21-3

Chemical Formula: C27H34N4O4S

Exact Mass: 510.2301

Molecular Weight: 510.65

Elemental Analysis: C, 63.51; H, 6.71; N, 10.97; O, 12.53; S, 6.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
VRT-325, VRT 325, VRT325; CFcor 325; CFcor-325; CFcor325;
IUPAC/Chemical Name
4-(cyclohexyloxy)-2-(1-{4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl}ethyl)quinazoline
InChi Key
FJNFVCAHHFNREI-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H34N4O4S/c1-20(30-16-18-31(19-17-30)36(32,33)23-14-12-21(34-2)13-15-23)26-28-25-11-7-6-10-24(25)27(29-26)35-22-8-4-3-5-9-22/h6-7,10-15,20,22H,3-5,8-9,16-19H2,1-2H3
SMILES Code
CC(C1=NC(OC2CCCCC2)=C3C=CC=CC3=N1)N4CCN(S(=O)(C5=CC=C(OC)C=C5)=O)CC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 510.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim Chiaw P, Wellhauser L, Huan LJ, Ramjeesingh M, Bear CE. A chemical corrector modifies the channel function of F508del-CFTR. Mol Pharmacol. 2010 Sep;78(3):411-8. doi: 10.1124/mol.110.065862. Epub 2010 May 25. PubMed PMID: 20501743.