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MedKoo Cat#: 525616 | Name: PI-091

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PI-091 is a platelet aggregation inhibitor.

Chemical Structure

PI-091
PI-091
CAS#129051-63-4

Theoretical Analysis

MedKoo Cat#: 525616

Name: PI-091

CAS#: 129051-63-4

Chemical Formula: C17H29NO4

Exact Mass: 311.2097

Molecular Weight: 311.42

Elemental Analysis: C, 65.57; H, 9.39; N, 4.50; O, 20.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PI-091
IUPAC/Chemical Name
(2R)-4-[2(S)-Hydroxy-2-methyloctanoyl]-2-isopropyl-2-methoxy-3-pyrrolin-5-one
InChi Key
ZPRHLCQHLGKOOC-IRXDYDNUSA-N
InChi Code
InChI=1S/C17H29NO4/c1-6-7-8-9-10-16(4,21)14(19)13-11-17(22-5,12(2)3)18-15(13)20/h11-12,21H,6-10H2,1-5H3,(H,18,20)/t16-,17-/m0/s1
SMILES Code
O=C1C(C([C@@](C)(O)CCCCCC)=O)=C[C@](OC)(C(C)C)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 311.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Uchiro H, Shionozaki N, Kobayakawa Y, Nakagawa H, Makino K. A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4765-8. doi: 10.1016/j.bmcl.2012.05.065. Epub 2012 May 24. PubMed PMID: 22704239. 2: Clark AJ, Dell CP, McDonagh JM, Geden J, Mawdsley P. Oxidative 5-endo cyclization of enamides mediated by ceric ammonium nitrate. Org Lett. 2003 Jun 12;5(12):2063-6. PubMed PMID: 12790529. 3: Iwasawa N, Maeyama K. A Highly Efficient Synthesis of (-)-PI-091 Construction of the 4-Alkoxy-2-butene-4-lactam Skeleton from Fischer-Type Carbene Complexes, Alkynyllithiums, and Tosyl Isocyanate. J Org Chem. 1997 Apr 4;62(7):1918-1919. PubMed PMID: 11671489. 4: Shiraki R, Sumino A, Tadano Ki KI, Ogawa S. Total Synthesis of Natural PI-091, a New Platelet Aggregation Inhibitor of Microbial Origin. J Org Chem. 1996 Apr 19;61(8):2845-2852. PubMed PMID: 11667121.