MedKoo Cat#: 525599 | Name: LAS191859

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LAS191859 is a novel, potent and selective CRTh2 antagonist.

Chemical Structure

LAS191859
LAS191859
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 525599

Name: LAS191859

CAS#: N/A

Chemical Formula: C25H26F3N3O3

Exact Mass: 473.1926

Molecular Weight: 473.50

Elemental Analysis: C, 63.42; H, 5.53; F, 12.04; N, 8.87; O, 10.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LAS191859
IUPAC/Chemical Name
3-(1-{2-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propionic acid
InChi Key
XETQGEXIEXEBRE-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H26F3N3O3/c1-15-2-7-20-17(5-9-23(33)34)14-31(24(20)30-15)21-8-6-19(25(26,27)28)12-18(21)13-29-11-10-22(32)16-3-4-16/h2,6-8,12,14,16,29H,3-5,9-11,13H2,1H3,(H,33,34)
SMILES Code
O=C(O)CCC1=CN(C2=CC=C(C(F)(F)F)C=C2CNCCC(C3CC3)=O)C4=NC(C)=CC=C41
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 473.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Calbet M, Andrés M, Armengol C, Bravo M, Eichhorn P, López R, García-González V, Roberts R, Miralpeix M. Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy. Pharmacol Res. 2016 Sep;111:208-16. doi: 10.1016/j.phrs.2016.06.014. Epub 2016 Jun 16. PubMed PMID: 27317944.