MedKoo Cat#: 532853 | Name: UAMC 00039 dihydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). UAMC 00039 dihydrochloride exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively).

Chemical Structure

UAMC 00039 dihydrochloride
UAMC 00039 dihydrochloride
CAS#697797-51-6

Theoretical Analysis

MedKoo Cat#: 532853

Name: UAMC 00039 dihydrochloride

CAS#: 697797-51-6

Chemical Formula: C16H26Cl3N3O

Exact Mass: 0.0000

Molecular Weight: 382.75

Elemental Analysis: C, 50.21; H, 6.85; Cl, 27.79; N, 10.98; O, 4.18

Price and Availability

Size Price Availability Quantity
1mg USD 210.00 2 Weeks
5mg USD 425.00 2 Weeks
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Related CAS #
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Synonym
UAMC00039, UAMC 00039, UAMC-00039, UAMC 00039 dihydrochloride, UAMC 00039 2HCl
IUPAC/Chemical Name
(2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
InChi Key
IWXMOQGMIWZNPR-CKUXDGONSA-N
InChi Code
InChI=1S/C16H24ClN3O.2ClH/c17-14-6-4-13(5-7-14)12-19-9-8-15(18)16(21)20-10-2-1-3-11-20;;/h4-7,15,19H,1-3,8-12,18H2;2*1H/t15-;;/m0../s1
SMILES Code
O=C(N1CCCCC1)[C@@H](N)CCNCC2=CC=C(Cl)C=C2.[H]Cl.[H]Cl
Appearance
Crystalline solid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
De Meester, I., Scharpé, S., Haemers, A., Lambeir, M. M., Polgar, L., Sedo, A., ... & Verkerk, R. (2008). 3rd International Conference on Dipeptidyl Peptidase and Related Proteins. Clin Chem Lab Med, 46(4), A1-A43. Van Goethem, S., Matheeussen, V., Joossens, J., Lambeir, A. M., Chen, X., De Meester, I., ... & Van der Veken, P. (2011). Structure–activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?. Journal of medicinal chemistry, 54(16), 5737-5746. Resnick, S. J., Iketani, S., Hong, S. J., Zask, A., Liu, H., Kim, S., ... & Chavez, A. (2021). Inhibitors of coronavirus 3CL proteases protect cells from protease-mediated cytotoxicity. Journal of Virology, 95(14), 10-1128.