UPCDC-30245 is a potent allosteric inhibitor of the AAA ATPase p97, exhibiting an IC₅₀ of approximately 27 nM. Structural studies using cryo-electron microscopy have elucidated its binding mechanism, revealing how UPCDC-30245 modulates p97 activity. In cellular assays, UPCDC-30245 has been shown to block endo-lysosomal degradation by inhibiting early endosome formation and reducing lysosomal acidity. This unique mechanism distinguishes it from other p97 inhibitors, such as CB-5083, and has demonstrated antiviral effects against coronaviruses by obstructing viral entry into host cells.
MedKoo Cat#: 525416
Name: UPCDC30245
CAS#: 1883351-01-6
Chemical Formula: C28H38FN5
Exact Mass: 463.3111
Molecular Weight: 463.65
Elemental Analysis: C, 72.54; H, 8.26; F, 4.10; N, 15.11
The following data is based on the product molecular weight 463.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
