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MedKoo Cat#: 530646 | Name: FITM
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

FITM is a potent mGlu1 inhibitor.

Chemical Structure

FITM
FITM
CAS#932737-65-0

Theoretical Analysis

MedKoo Cat#: 530646

Name: FITM

CAS#: 932737-65-0

Chemical Formula: C18H18FN5OS

Exact Mass: 371.1216

Molecular Weight: 371.43

Elemental Analysis: C, 58.21; H, 4.88; F, 5.11; N, 18.86; O, 4.31; S, 8.63

Price and Availability

Size Price Availability Quantity
100mg USD 850.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 4,850.00 2 Weeks
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Related CAS #
No Data
Synonym
FITM
IUPAC/Chemical Name
4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide
InChi Key
WIVGIKIKQHUFOD-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18FN5OS/c1-11(2)22-16-8-14(20-10-21-16)15-9-26-18(23-15)24(3)17(25)12-4-6-13(19)7-5-12/h4-11H,1-3H3,(H,20,21,22)
SMILES Code
O=C(N(C1=NC(C2=NC=NC(NC(C)C)=C2)=CS1)C)C3=CC=C(F)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 371.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu X, Ren C, Lu Y, Liu Y, Kim JH, Leutgeb S, Komiyama T, Kuzum D. Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical- hippocampal interactions. Nat Neurosci. 2021 Jun;24(6):886-896. doi: 10.1038/s41593-021-00841-5. Epub 2021 Apr 19. PMID: 33875893; PMCID: PMC8627685. 2: Hayes M, Choudhary V, Ojha N, Shin JJ, Han GS, Carman GM, Loewen CJ, Prinz WA, Levine T. Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes. Microb Cell. 2017 Dec 28;5(2):88-103. doi: 10.15698/mic2018.02.614. PMID: 29417057; PMCID: PMC5798408. 3: Yamasaki T, Fujinaga M, Maeda J, Kawamura K, Yui J, Hatori A, Yoshida Y, Nagai Y, Tokunaga M, Higuchi M, Suhara T, Fukumura T, Zhang MR. Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM. Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):632-41. doi: 10.1007/s00259-011-1995-6. Epub 2011 Nov 24. PMID: 22113620. 4: Yuan G, Shoup TM, Moon SH, Brownell AL. A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes. RSC Adv. 2020 Jul 2;10(42):25223-25227. doi: 10.1039/d0ra04943c. PMID: 33014351; PMCID: PMC7497470. 5: Xie L, Yui J, Fujinaga M, Hatori A, Yamasaki T, Kumata K, Wakizaka H, Furutsuka K, Takei M, Jin ZH, Furukawa T, Kawamura K, Zhang MR. Molecular imaging of ectopic metabotropic glutamate 1 receptor in melanoma with a positron emission tomography radioprobe (18) F-FITM. Int J Cancer. 2014 Oct 15;135(8):1852-9. doi: 10.1002/ijc.28842. Epub 2014 Mar 19. PMID: 24643962. 6: Yamasaki T, Fujinaga M, Kawamura K, Yui J, Hatori A, Ohya T, Xie L, Wakizaka H, Yoshida Y, Fukumura T, Zhang MR. In vivo measurement of the affinity and density of metabotropic glutamate receptor subtype 1 in rat brain using 18F-FITM in small-animal PET. J Nucl Med. 2012 Oct;53(10):1601-7. doi: 10.2967/jnumed.112.105908. Epub 2012 Aug 22. PMID: 22915159.