Synonym
SNC80; SNC-80; SNC80.
IUPAC/Chemical Name
4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
InChi Key
KQWVAUSXZDRQPZ-UMTXDNHDSA-N
InChi Code
InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
SMILES Code
O=C(N(CC)CC)C1=CC=C([C@@H](N2[C@@H](C)CN(CC=C)[C@H](C)C2)C3=CC=CC(OC)=C3)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
SNC 80 is a highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.
In vitro activity:
This study demonstrates that SNC 80 a unique substance that selectively influences slow but not fast inactivation processes in Na+ channels. In rat hippocampal granule cells, SNC 80 caused a concentration-dependent block of peak Na+ current amplitude, with a notable impact on slow inactivation processes. It selectively increased the fraction of Na+ channels undergoing slow inactivation during prolonged depolarization, while fast recovery processes remained unaffected.
Reference: Neuropharmacology. 2004 Dec;47(7):1102-12. https://pubmed.ncbi.nlm.nih.gov/15555644/
In vivo activity:
SNC 80 mitigates Parkinson's disease (PD)-related issues, such as replenishing motor functions, through UPR and inflammation regulation. In a mouse model of PD, SNC 80 administration significantly improved motor functions by reducing UPR stress sensors and inflammatory cytokines. It also upregulated Nrf-2 and HO-1 proteins, indicating antioxidant effects.
Reference: Neurosci Lett. 2018 Jun 21;678:29-36. https://pubmed.ncbi.nlm.nih.gov/29727730/
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMSO |
9.0 |
20.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
449.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Lin YY, Wu DM, Liu L, Liu QH, Yan ZY, Wu BW. Activation of δ-opioid receptors inhibits L-type Ca(2+) current and transient outward K(+) current in rat ventricular myocytes. Sheng Li Xue Bao. 2008 Feb 25;60(1):38-42. PMID: 18288356.
2. Remy C, Remy S, Beck H, Swandulla D, Hans M. Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology. 2004 Dec;47(7):1102-12. doi: 10.1016/j.neuropharm.2004.06.034. PMID: 15555644.
3. Sakamoto K, Yamada D, Yamanaka N, Nishida M, Iio K, Nagase H, Saitoh A. A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice. Brain Res. 2021 Apr 15;1757:147297. doi: 10.1016/j.brainres.2021.147297. Epub 2021 Jan 29. PMID: 33516811.
4. Begum M ET, Sen D. DOR agonist (SNC-80) exhibits anti-parkinsonian effect via downregulating UPR/oxidative stress signals and inflammatory response in vivo. Neurosci Lett. 2018 Jun 21;678:29-36. doi: 10.1016/j.neulet.2018.04.055. Epub 2018 May 1. PMID: 29727730.
In vitro protocol:
1. Lin YY, Wu DM, Liu L, Liu QH, Yan ZY, Wu BW. Activation of δ-opioid receptors inhibits L-type Ca(2+) current and transient outward K(+) current in rat ventricular myocytes. Sheng Li Xue Bao. 2008 Feb 25;60(1):38-42. PMID: 18288356.
2. Remy C, Remy S, Beck H, Swandulla D, Hans M. Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology. 2004 Dec;47(7):1102-12. doi: 10.1016/j.neuropharm.2004.06.034. PMID: 15555644.
In vivo protocol:
1. Sakamoto K, Yamada D, Yamanaka N, Nishida M, Iio K, Nagase H, Saitoh A. A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice. Brain Res. 2021 Apr 15;1757:147297. doi: 10.1016/j.brainres.2021.147297. Epub 2021 Jan 29. PMID: 33516811.
2. Begum M ET, Sen D. DOR agonist (SNC-80) exhibits anti-parkinsonian effect via downregulating UPR/oxidative stress signals and inflammatory response in vivo. Neurosci Lett. 2018 Jun 21;678:29-36. doi: 10.1016/j.neulet.2018.04.055. Epub 2018 May 1. PMID: 29727730.
1: Chung PC, Boehrer A, Stephan A, Matifas A, Scherrer G, Darcq E, Befort K, Kieffer BL. Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures. Behav Brain Res. 2015 Feb 1;278:429-34. doi: 10.1016/j.bbr.2014.10.029. Epub 2014 Oct 30. PubMed PMID: 25447299; PubMed Central PMCID: PMC4382405.
2: Bosse KE, Jutkiewicz EM, Schultz-Kuszak KN, Mabrouk OS, Kennedy RT, Gnegy ME, Traynor JR. Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism. Neuropharmacology. 2014 Feb;77:19-27. doi: 10.1016/j.neuropharm.2013.08.027. Epub 2013 Sep 10. PubMed PMID: 24035916; PubMed Central PMCID: PMC3970824.
3: Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther. 2013 Nov;347(2):258-64. doi: 10.1124/jpet.113.206573. Epub 2013 Aug 26. PubMed PMID: 23978562; PubMed Central PMCID: PMC3807063.
