Synonym
SNAP-7941; SNAP 7941; SNAP7941.
IUPAC/Chemical Name
methyl (6S)-1-[3-[4-(3-acetamidophenyl)piperidin-1-yl]propylcarbamoyl]-6-(3,4-difluorophenyl)-4-(methoxymethyl)-2-oxo-3,6-dihydropyrimidine-5-carboxylate
InChi Key
FWMHZWMPUWAUPL-NDEPHWFRSA-N
InChi Code
InChI=1S/C31H37F2N5O6/c1-19(39)35-23-7-4-6-21(16-23)20-10-14-37(15-11-20)13-5-12-34-30(41)38-28(22-8-9-24(32)25(33)17-22)27(29(40)44-3)26(18-43-2)36-31(38)42/h4,6-9,16-17,20,28H,5,10-15,18H2,1-3H3,(H,34,41)(H,35,39)(H,36,42)/t28-/m0/s1
SMILES Code
O=C(C([C@H](C1=CC=C(F)C(F)=C1)N2C(NCCCN3CCC(C4=CC=CC(NC(C)=O)=C4)CC3)=O)=C(COC)NC2=O)OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
613.66
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schirmer E, Shanab K, Datterl B, Neudorfer C, Mitterhauser M, Wadsak W, Philippe C, Spreitzer H. Syntheses of precursors and reference compounds of the melanin-concentrating hormone receptor 1 (MCHR1) tracers [¹¹C]SNAP-7941 and [¹⁸F]FE@SNAP for positron emission tomography. Molecules. 2013 Sep 30;18(10):12119-43. doi: 10.3390/molecules181012119. PubMed PMID: 24084017.
2: Philippe C, Nics L, Zeilinger M, Kuntner C, Wanek T, Mairinger S, Shanab K, Spreitzer H, Viernstein H, Wadsak W, Mitterhauser M. Preclinical in vitro &in vivo evaluation of [(11)C]SNAP-7941 - the first PET tracer for the melanin concentrating hormone receptor 1. Nucl Med Biol. 2013 Oct;40(7):919-25. doi: 10.1016/j.nucmedbio.2013.05.010. Epub 2013 Jul 3. PubMed PMID: 23829932.
3: Philippe C, Schirmer E, Mitterhauser M, Shanab K, Lanzenberger R, Karanikas G, Spreitzer H, Viernstein H, Wadsak W. Radiosynthesis of [11C]SNAP-7941--the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1). Appl Radiat Isot. 2012 Oct;70(10):2287-94. doi: 10.1016/j.apradiso.2012.07.010. Epub 2012 Jul 20. PubMed PMID: 22858577; PubMed Central PMCID: PMC3439630.
4: Goss JM, Schaus SE. Enantioselective synthesis of SNAP-7941: chiral dihydropyrimidone inhibitor of MCH1-R. J Org Chem. 2008 Oct 3;73(19):7651-6. doi: 10.1021/jo801463j. Epub 2008 Sep 4. PubMed PMID: 18767801; PubMed Central PMCID: PMC2666257.
5: Millan MJ, Gobert A, Panayi F, Rivet JM, Dekeyne A, Brocco M, Ortuno JC, Di Cara B. The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats. Int J Neuropsychopharmacol. 2008 Dec;11(8):1105-22. doi: 10.1017/S1461145708008894. Epub 2008 May 9. PubMed PMID: 18466669.
6: Doggrell SA. Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As? Expert Opin Investig Drugs. 2003 Jun;12(6):1035-8. Review. PubMed PMID: 12783607.
