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MedKoo Cat#: 525246 | Name: AFC

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AFC is a fluorescent marker; Substrate for fluorogenic enzyme assays.

Chemical Structure

AFC
AFC
CAS#53518-15-3

Theoretical Analysis

MedKoo Cat#: 525246

Name: AFC

CAS#: 53518-15-3

Chemical Formula: C10H6F3NO2

Exact Mass: 229.0351

Molecular Weight: 229.16

Elemental Analysis: C, 52.41; H, 2.64; F, 24.87; N, 6.11; O, 13.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AFC
IUPAC/Chemical Name
7-Amino-4-trifluoromethylcoumarin
InChi Key
JBNOVHJXQSHGRL-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H6F3NO2/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4H,14H2
SMILES Code
O=C1OC2=C(C=CC(N)=C2)C(C(F)(F)F)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 229.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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[Epub ahead of print] PubMed PMID: 28493138. 4: Kiranmayee D, Praveena T, Himabindu Y, Sriharibabu M, Kavya K, Mahalakshmi M. The Effect of Moderate Physical Activity on Ovarian Reserve Markers in Reproductive Age Women Below and Above 30 Years. J Hum Reprod Sci. 2017 Jan-Mar;10(1):44-48. doi: 10.4103/jhrs.JHRS_98_16. PubMed PMID: 28479755; PubMed Central PMCID: PMC5405647. 5: Hu Q, Hong L, Nie M, Wang Q, Fang Y, Dai Y, Zhai Y, Wang S, Yin C, Yang X. The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women. J Ovarian Res. 2017 May 4;10(1):32. doi: 10.1186/s13048-017-0326-3. PubMed PMID: 28472976; PubMed Central PMCID: PMC5418866. 6: Pastuszek E, Lukaszuk A, Kunicki M, Mockun J, Kloss G, Malinowska I, Czyzyk A, Meczekalski B, Lukaszuk K. New AMH assay allows rapid point of care measurements of ovarian reserve. Gynecol Endocrinol. 2017 May 1:1-6. doi: 10.1080/09513590.2017.1306735. [Epub ahead of print] PubMed PMID: 28457181. 7: Bhide P, Kulkarni A, Dilgil M, Dhir P, Shah A, Gudi A, Homburg R. Phenotypic variation in anti-Mullerian hormone (AMH) production per follicle in women with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM): an observational cross-sectional study. Gynecol Endocrinol. 2017 Apr 28:1-6. doi: 10.1080/09513590.2017.1320377. [Epub ahead of print] PubMed PMID: 28454499. 8: Bas-Lando M, Rabinowitz R, Farkash R, Algur N, Rubinstein E, Schonberger O, Eldar-Geva T. Prediction value of anti-Mullerian hormone (AMH) serum levels and antral follicle count (AFC) in hormonal contraceptive (HC) users and non-HC users undergoing IVF-PGD treatment. Gynecol Endocrinol. 2017 Apr 28:1-4. doi: 10.1080/09513590.2017.1320376. [Epub ahead of print] PubMed PMID: 28454495. 9: Zhang W, Chen F, Wang Z, Huang J, Wang B. Evaluation of Carbon Emission Reductions Promoted by Private Driving Restrictions Based on AFC Data in Beijing. J Air Waste Manag Assoc. 2017 Apr 28. doi: 10.1080/10962247.2017.1320597. [Epub ahead of print] PubMed PMID: 28453402. 10: Chen Y, Ye B, Yang X, Zheng J, Lin J, Zhao J. Predicting the outcome of different protocols of in vitro fertilization with anti-Muüllerian hormone levels in patients with polycystic ovary syndrome. J Int Med Res. 2017 Jan 1:300060517704140. doi: 10.1177/0300060517704140. [Epub ahead of print] PubMed PMID: 28449632. 11: Lockmann ALV, Mourão FAG, Moraes MFD. Auditory fear conditioning modifies steady-state evoked potentials in the rat inferior colliculus. J Neurophysiol. 2017 Apr 26:jn.00293.2017. doi: 10.1152/jn.00293.2017. [Epub ahead of print] PubMed PMID: 28446582. 12: Huppert LA, Matthay MA. Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome. Front Immunol. 2017 Apr 7;8:371. doi: 10.3389/fimmu.2017.00371. eCollection 2017. Review. PubMed PMID: 28439268; PubMed Central PMCID: PMC5383664. 13: Dorr M, Lesmes LA, Elze T, Wang H, Lu ZL, Bex PJ. Evaluation of the precision of contrast sensitivity function assessment on a tablet device. Sci Rep. 2017 Apr 21;7:46706. doi: 10.1038/srep46706. PubMed PMID: 28429773; PubMed Central PMCID: PMC5399462. 14: Zebitay AG, Cetin O, Verit FF, Keskin S, Sakar MN, Karahuseyinoglu S, Ilhan G, Sahmay S. The role of ovarian reserve markers in prediction of clinical pregnancy. J Obstet Gynaecol. 2017 May;37(4):492-497. doi: 10.1080/01443615.2016.1269730. Epub 2017 Feb 17. PubMed PMID: 28421902. 15: Wang Y, Gonzales E, Morrow-Howell N. Applying WHO's Age-Friendly Communities Framework to a National Survey in China. J Gerontol Soc Work. 2017 Apr;60(3):215-231. doi: 10.1080/01634372.2017.1292980. Epub 2017 Feb 22. PubMed PMID: 28409710. 16: Agarwal R, Shruthi R, Radhakrishnan G, Singh A. Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study. J Obstet Gynaecol India. 2017 Apr;67(2):137-142. doi: 10.1007/s13224-016-0941-8. Epub 2016 Sep 19. PubMed PMID: 28405122; PubMed Central PMCID: PMC5371526. 17: Orpana H, Vachon J, Dykxhoorn J, Jayaraman G. Measuring positive mental health in Canada: construct validation of the Mental Health Continuum-Short Form. Health Promot Chronic Dis Prev Can. 2017 Apr;37(4):123-130. doi: 10.24095/hpcdp.37.4.03. English, French. PubMed PMID: 28402801. 18: D'Avila ÂM, Capp E, Corleta HVE. Antral Follicles Count and Anti-Müllerian Hormone Levels after Gonadotoxic Chemotherapy in Patients with Breast Cancer: Cohort Study. Rev Bras Ginecol Obstet. 2017 Apr;39(4):162-168. doi: 10.1055/s-0037-1601438. Epub 2017 Apr 11. PubMed PMID: 28399596. 19: Depmann M, Broer SL, Eijkemans MJ, van Rooij IA, Scheffer GJ, Heimensem J, Mol BW, Broekmans FJ. Anti-Müllerian hormone does not predict time to pregnancy: results of a prospective cohort study. Gynecol Endocrinol. 2017 Apr 10:1-5. doi: 10.1080/09513590.2017.1306848. [Epub ahead of print] PubMed PMID: 28393651. 20: Chaib I, Karachaliou N, Pilotto S, Codony Servat J, Cai X, Li X, Drozdowskyj A, Servat CC, Yang J, Hu C, Cardona AF, Vivanco GL, Vergnenegre A, Sanchez JM, Provencio M, Reguart N, Zhou C, Cao P, Ma PC, Bivona TG, Rosell R. Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC. J Natl Cancer Inst. 2017 Sep 1;109(9). doi: 10.1093/jnci/djx014. PubMed PMID: 28376152; PubMed Central PMCID: PMC5409000.

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