Synonym
TCS2312, TCS 2312, TCS-2312;
IUPAC/Chemical Name
4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
InChi Key
JMEXWOPTERDPHI-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H24N4O2/c30-21-10-11-22(24(31)13-21)17-4-6-18(7-5-17)23-14-25(29-28-23)27-20-3-1-2-16(12-20)15-26-19-8-9-19/h1-7,10-14,19,26,30-31H,8-9,15H2,(H2,27,28,29)
SMILES Code
OC1=CC(O)=CC=C1C2=CC=C(C3=NNC(NC4=CC=CC(CNC5CC5)=C4)=C3)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
412.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sproul CD, Rao S, Ibrahim JG, Kaufmann WK, Cordeiro-Stone M. Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis? Cell Cycle. 2013 Nov 15;12(22):3555-63. doi: 10.4161/cc.26590. Epub 2013 Sep 25. PubMed PMID: 24091629; PubMed Central PMCID: PMC3906341.
2: Cole KA, Huggins J, Laquaglia M, Hulderman CE, Russell MR, Bosse K, Diskin SJ, Attiyeh EF, Sennett R, Norris G, Laudenslager M, Wood AC, Mayes PA, Jagannathan J, Winter C, Mosse YP, Maris JM. RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3336-41. doi: 10.1073/pnas.1012351108. Epub 2011 Feb 2. PubMed PMID: 21289283; PubMed Central PMCID: PMC3044382.
3: Shen T, Zhou H, Shang C, Luo Y, Wu Y, Huang S. Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation. Genes Cancer. 2018 Jan;9(1-2):39-52. doi: 10.18632/genesandcancer.166. PMID: 29725502; PMCID: PMC5931253.
