MedKoo Cat#: 525220 | Name: Deoxynybomycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deoxynybomycin is a selective anti-tumor agent, inducing apoptosis and inhibiting topoisomerase I.

Chemical Structure

Deoxynybomycin
Deoxynybomycin
CAS#27259-98-9

Theoretical Analysis

MedKoo Cat#: 525220

Name: Deoxynybomycin

CAS#: 27259-98-9

Chemical Formula: C16H14N2O3

Exact Mass: 282.1004

Molecular Weight: 282.30

Elemental Analysis: C, 68.08; H, 5.00; N, 9.92; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Deoxynybomycin
IUPAC/Chemical Name
5,7,10-Trimethyl-10H-1-oxa-2a,10-diaza-aceanthrylene-3,9-dione
InChi Key
SBTFHJGTXHMDPR-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14N2O3/c1-8-4-12(19)17(3)14-10(8)6-11-9(2)5-13(20)18-7-21-16(14)15(11)18/h4-6H,7H2,1-3H3
SMILES Code
O=C(C=C1C)N2COC3=C2C1=CC(C(C)=C4)=C3N(C)C4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Richter MF, Drown BS, Riley AP, Garcia A, Shirai T, Svec RL, Hergenrother PJ. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature. 2017 May 10. doi: 10.1038/nature22308. [Epub ahead of print] PubMed PMID: 28489819. 2: Parkinson EI, Bair JS, Nakamura BA, Lee HY, Kuttab HI, Southgate EH, Lezmi S, Lau GW, Hergenrother PJ. Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nat Commun. 2015 Apr 24;6:6947. doi: 10.1038/ncomms7947. PubMed PMID: 25907309; PubMed Central PMCID: PMC4421842. 3: Egawa K, Yamori T, Nosaka C, Kunimoto S, Takeuchi T, Nos K. Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I. Biol Pharm Bull. 2000 Sep;23(9):1036-40. PubMed PMID: 10993200. 4: Pope JA Jr, Nelson RA, Schaffner CP, Rosen RT, Pandey RC. Applications of thin layer chromatography, high performance liquid chromatography and mass spectrometry in the fermentation and isolation of the antibiotic nybomycin. J Ind Microbiol. 1990 Sep;6(1):61-9. PubMed PMID: 1369285. 5: Forbis RM, Rinehart KL Jr. Nybomycin. VII. Preparative routes to nybomycin and deoxynybomycin. J Am Chem Soc. 1973 Jul 25;95(15):5003-13. PubMed PMID: 4741283. 6: Forbis RM, Rinehart KL Jr. Nybomycin. IV. Total synthesis of deoxynybomycin. J Am Chem Soc. 1970 Nov 18;92(23):6995-6. PubMed PMID: 5483075. 7: Naganawa H, Wakashiro T, Yagi A, Kondo S, Takita T. Deoxynybomycin from a streptomyces. J Antibiot (Tokyo). 1970 Jul;23(7):365-8. PubMed PMID: 5460278.