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MedKoo Cat#: 525214 | Name: BKM-570

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BKM-570 is a bradykinin antagonist, causing impressive growth inhibition of lung and prostate tumors, displaying superior in vivo inhibitory effects than convential chemotherapeutic drugs.

Chemical Structure

BKM-570
BKM-570
CAS#259885-54-6

Theoretical Analysis

MedKoo Cat#: 525214

Name: BKM-570

CAS#: 259885-54-6

Chemical Formula: C34H35Cl2F5N4O3

Exact Mass: 712.2006

Molecular Weight: 713.57

Elemental Analysis: C, 57.23; H, 4.94; Cl, 9.94; F, 13.31; N, 7.85; O, 6.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BKM-570
IUPAC/Chemical Name
2,3,4,5,6-Pentafluorocinnamoyl-(O-2,6-dichlorobenzyl)-L-tyrosine-N-(4-amino-2,2,6,6-tetramethyl-piperidyl)amide
InChi Key
LQHZEXWBMDTGEB-SDQWYYNMSA-N
InChi Code
InChI=1S/C34H35Cl2F5N4O3/c1-33(2)15-19(42)16-34(3,4)45(33)44-32(47)25(43-26(46)13-12-21-27(37)29(39)31(41)30(40)28(21)38)14-18-8-10-20(11-9-18)48-17-22-23(35)6-5-7-24(22)36/h5-13,19,25H,14-17,42H2,1-4H3,(H,43,46)(H,44,47)/b13-12+/t25-/m0/s1
SMILES Code
O=C(NN1C(C)(C)CC(N)CC1(C)C)[C@H](CC2=CC=C(OCC3=C(Cl)C=CC=C3Cl)C=C2)NC(/C=C/C4=C(F)C(F)=C(F)C(F)=C4F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 713.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Avdieiev S, Gera L, Havrylyuk D, Hodges RS, Lesyk R, Ribrag V, Vassetzky Y, Kavsan V. Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds. Bioorg Med Chem. 2014 Aug 1;22(15):3815-23. doi: 10.1016/j.bmc.2014.06.046. Epub 2014 Jun 30. PubMed PMID: 25012567. 2: Jutras S, Bachvarova M, Keita M, Bascands JL, Mes-Masson AM, Stewart JM, Gera L, Bachvarov D. Strong cytotoxic effect of the bradykinin antagonist BKM-570 in ovarian cancer cells--analysis of the molecular mechanisms of its antiproliferative action. FEBS J. 2010 Dec;277(24):5146-60. doi: 10.1111/j.1742-4658.2010.07928.x. Epub 2010 Nov 16. Erratum in: FEBS J. 2011 Apr;278(6):999. Gera, Lajos [added]. PubMed PMID: 21078129. 3: Stewart JM, Gera L, Chan DC, York EJ, Simkeviciene V, Bunn PA Jr, Taraseviciene-Stewart L. Combination cancer chemotherapy with one compound: pluripotent bradykinin antagonists. Peptides. 2005 Aug;26(8):1288-91. PubMed PMID: 15878795. 4: Stewart JM, Gera L, Chan DC, Bunn PA Jr, York EJ, Simkeviciene V, Helfrich B. Bradykinin-related compounds as new drugs for cancer and inflammation. Can J Physiol Pharmacol. 2002 Apr;80(4):275-80. PubMed PMID: 12025961.