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MedKoo Cat#: 532695 | Name: SCH-900229

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SCH-900229 is a potent presenilin 1 selective γ-secretase inhibitor for the treatment of Alzheimer’s Disease.

Chemical Structure

SCH-900229
SCH-900229
CAS#1100361-36-1

Theoretical Analysis

MedKoo Cat#: 532695

Name: SCH-900229

CAS#: 1100361-36-1

Chemical Formula: C21H21ClF2O6S2

Exact Mass: 506.0436

Molecular Weight: 506.96

Elemental Analysis: C, 49.75; H, 4.18; Cl, 6.99; F, 7.50; O, 18.94; S, 12.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SCH-900229; SCH 900229; SCH900229.
IUPAC/Chemical Name
(4S,4aS,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-4-(2-methylsulfonylethyl)-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromene
InChi Key
AMXSRXZYBDALJG-XERREHJYSA-N
InChi Code
InChI=1S/C21H21ClF2O6S2/c1-31(25,26)11-8-18-15-12-30-20-17(24)7-6-16(23)19(20)21(15,9-10-29-18)32(27,28)14-4-2-13(22)3-5-14/h2-7,15,18H,8-12H2,1H3/t15-,18-,21-/m0/s1
SMILES Code
O=S(CC[C@@H]1OCC[C@]2(S(=O)(C3=CC=C(Cl)C=C3)=O)[C@@]1([H])COC4=C2C(F)=CC=C4F)(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 506.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu WL, Burnett DA, Clader J, Greenlee WJ, Jiang Q, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841. doi: 10.1016/j.bmcl.2016.04.095. Epub 2016 May 7. PubMed PMID: 27836402. 2: Wu WL, Sasikumar TK, Domalski MS, Qiang L, Burnett DA, Clader J, Greenlee WJ, Chan TM, Lee J, Zhang L. A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors. Bioorg Med Chem Lett. 2013 Feb 1;23(3):850-3. doi: 10.1016/j.bmcl.2012.11.054. Epub 2012 Nov 28. PubMed PMID: 23265902. 3: Wu WL, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee WJ, Josien H, McBriar M, Rajagopalan M, Vicarel M, Xu R, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors. Bioorg Med Chem Lett. 2013 Feb 1;23(3):844-9. doi: 10.1016/j.bmcl.2012.11.047. Epub 2012 Nov 24. PubMed PMID: 23265892. 4: Wu WL, Domalski M, Burnett DA, Josien H, Bara T, Rajagopalan M, Xu R, Clader J, Greenlee WJ, Brunskill A, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease. ACS Med Chem Lett. 2012 Apr 9;3(11):892-6. doi: 10.1021/ml300044f. eCollection 2012 Nov 8. PubMed PMID: 24900404; PubMed Central PMCID: PMC4025742.