SC-51322 | CAS# 146032-79-3 | EP1 Antagonist |MedKoo

MedKoo Cat#: 532687 | Name: SC-51322

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg.

Chemical Structure

SC-51322

CAS#146032-79-3

Theoretical Analysis

MedKoo Cat#: 532687

Name: SC-51322

CAS#: 146032-79-3

Chemical Formula: C22H20ClN3O4S

Exact Mass: 457.0863

Molecular Weight: 457.93

Elemental Analysis: C, 57.70; H, 4.40; Cl, 7.74; N, 9.18; O, 13.98; S, 7.00

Price and Availability

Size	Price	Availability
5mg	USD 250.00	2 Weeks
10mg	USD 450.00	2 Weeks
25mg	USD 800.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

SC-51322; SC 51322; SC51322.

IUPAC/Chemical Name

3-chloro-N'-[3-(furan-2-ylmethylsulfanyl)propanoyl]-6H-benzo[b][1,5]benzoxazepine-5-carbohydrazide

InChi Key

CQBVTZDISUKDSX-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H20ClN3O4S/c23-16-7-8-20-18(12-16)26(13-15-4-1-2-6-19(15)30-20)22(28)25-24-21(27)9-11-31-14-17-5-3-10-29-17/h1-8,10,12H,9,11,13-14H2,(H,24,27)(H,25,28)

SMILES Code

ClC(C=C1)=CC2=C1OC3=CC=CC=C3CN2C(NNC(CCSCC4=CC=CO4)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, DMF, and ethanol

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SC-51322 is an antagonist of the PGE2 receptor EP 1, with a pA2 of 8.1.

In vitro activity:

SC-51322 is a potent PGE2 antagonist (pA2 = 8.1) and analgesic (ED50 = 0.9 mg/kg). SC-51322 is the most potent PGE2 antagonist and analgesic that has been seen in the N-substituted dibenzoxazepines series. Reference: Bioorganic & Medicinal Chemistry Letters. Feb 1994. https://doi.org/10.1016/0960-894X(94)80027-8.

In vivo activity:

To determined

	Solvent	mg/mL	mM
Solubility
	DMF	20.0	43.67
	DMSO	20.0	43.67
	Ethanol	30.0	65.51

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 457.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Hallinan EA, Hagen TJ, Tsymbalov S, Husa RK, Lee AC, Stapelfeld A, Savage MA. Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs. J Med Chem. 1996 Jan 19;39(2):609-13. doi: 10.1021/jm950454k. PMID: 8558534. 2. Hallinan EA, et, al. 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic. Bioorganic & Medicinal Chemistry Letters. Feb 1994. 4(3): 509-514.

In vitro protocol:

In vivo protocol:

To be determined

1. Hallinan, E.A.,Hagen, T.J.,Tsymbalov, S., et al. Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs. Journal of Medicinal Chemistry 39, 609-613 (1996). 2. Foudi, N.,Kotelevets, L.,Louedec, L., et al. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: Role of the EP4 receptor subtype. British Journal of Pharmacology 154, 1631-1639 (2008).