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MedKoo Cat#: 532681 | Name: SC-19220

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC-19220 is a prostaglandin E2 antagonist, inhibits osteoclast formation by 1,25-dihydroxyvitamin D3 in cell cultures.

Chemical Structure

SC-19220
SC-19220
CAS#19395-87-0

Theoretical Analysis

MedKoo Cat#: 532681

Name: SC-19220

CAS#: 19395-87-0

Chemical Formula: C16H19ClN3O3

Exact Mass: 336.1115

Molecular Weight: 336.80

Elemental Analysis: C, 57.06; H, 5.69; Cl, 10.53; N, 12.48; O, 14.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SC-19220; SC 19220; SC19220.
IUPAC/Chemical Name
N'-acetyl-3-chloro-6H-benzo[b][1,5]benzoxazepine-5-carbohydrazide
InChi Key
GJXZKCLXQFGXBS-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19ClN3O3/c1-10(21)19-20-16(22)23-14-5-3-2-4-13(14)18-9-11-6-7-12(17)8-15(11)23/h2-3,6-9,13-15,18H,4-5H2,1H3,(H,19,21)(H,20,22)
SMILES Code
O=C(O1C2C(C=CC(Cl)=C2)=CNC3C1CC=CC3)NNC(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tsujisawa T, Inoue H, Nishihara T. SC-19220, antagonist of prostaglandin E2 receptor EP1, inhibits osteoclastogenesis by RANKL. J Bone Miner Res. 2005 Jan;20(1):15-22. Epub 2004 Oct 18. PubMed PMID: 15619665. 2: Santangelo S, Shoup M, Gamelli RL, Shankar R. Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis. J Trauma. 2000 May;48(5):826-30; discussion 830-1. PubMed PMID: 10823525. 3: Inoue H, Tsujisawa T, Fukuizumi T, Kawagishi S, Uchiyama C. SC-19220, a prostaglandin E2 antagonist, inhibits osteoclast formation by 1,25-dihydroxyvitamin D3 in cell cultures. J Endocrinol. 1999 May;161(2):231-6. PubMed PMID: 10320820. 4: Vassilev P, Radomirov R. Contractile effects of prostaglandin E2 in rat rectum: sensitivity to the prostaglandin antagonists diphloretin phosphate and SC 19220. Prostaglandins. 1992 Nov;44(5):471-83. PubMed PMID: 1361677. 5: Kimoto Y, Constantinou CE. Regional effects of indomethacin, acetylsalicylic acid and SC-19220 on the contractility of rabbit renal pelvis (pacemaker regions and pelviureteric junction). J Urol. 1991 Aug;146(2):433-8. PubMed PMID: 1677433. 6: Maggi CA, Giuliani S, Patacchini R, Conte B, Furio M, Santicioli P, Meli P, Gragnani L, Meli A. The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. Eur J Pharmacol. 1988 Aug 2;152(3):273-9. PubMed PMID: 2906002. 7: Rakovska A, Milenov K. Antagonistic effect of SC-19220 on the responses of guinea-pig gastric muscles to prostaglandins E1, E2 and F2 alpha. Arch Int Pharmacodyn Ther. 1984 Mar;268(1):59-69. PubMed PMID: 6145394. 8: Juan H, Seewann S. Selective reduction by some vasodilators and the prostaglandin antagonist SC-19220 of a response to the algesic effect of bradykinin. Eur J Pharmacol. 1980 Jul 25;65(2-3):267-78. PubMed PMID: 6105087. 9: Bennett A, Jarosik C, Sanger GJ, Wilson DE. Antagonism of prostanoid-induced contractions of rat gastric fundus muscle by SC-19220, sodium meclofenamate, indomethacin or trimethoquinol. Br J Pharmacol. 1980;71(1):169-75. PubMed PMID: 6110453; PubMed Central PMCID: PMC2044421. 10: Clark WG, Cumby HR. Effects of prostaglandin antagonist SC-19220 on body temperature and on hyperthermic responses to prostaglandin E-1 and leukocytic pyrogen in the cat. Prostaglandins. 1975 Mar;9(3):361-8. PubMed PMID: 1138292. 11: Lambley JE, Smith AP. The effects of arachidonic acid, indomethacin and SC-19220 on guinea-pig tracheal muscle tone. Eur J Pharmacol. 1975 Feb;30(2):148-53. PubMed PMID: 236189. 12: Farmer JB, Farrar DG, Wilson J. Antagonism of tone and prostaglandin-mediated responses in a tracheal preparation by indomethacin and SC-19220. Br J Pharmacol. 1974 Dec;52(4):559-65. PubMed PMID: 4455330; PubMed Central PMCID: PMC1776897. 13: Engel JJ, Scruggs W, Wilson DE. Failure of SC-19220 to affect prostaglandin E1 (PGR1) gastric antisecretory actions. Prostaglandins. 1973 Jul;4(1):65-70. PubMed PMID: 4199539. 14: Radzialowski FM, Novak L. Reversal of the antilipolytic effect of prostaglandin E 2 by an oxazepine derivative (SC-19220). Life Sci I. 1971 Nov 15;10(22):1261-5. PubMed PMID: 5004183. 15: Sanner JH. Antagonism of prostaglandin E2 by 1-acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f) (1,4) oxazepine-10-carbonyl) hydrazine (SC-19220). Arch Int Pharmacodyn Ther. 1969 Jul;180(1):46-56. PubMed PMID: 4982414.

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inS3-54-A18

inS3-54-A18