MedKoo Cat#: 540029 | Name: Aristolochic acid B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aristolochic acid B is a carcinogen found in Aristolochia and Radix. It inhibits PLA2.

Chemical Structure

Aristolochic acid B
Aristolochic acid B
CAS#475-80-9

Theoretical Analysis

MedKoo Cat#: 540029

Name: Aristolochic acid B

CAS#: 475-80-9

Chemical Formula: C16H9NO6

Exact Mass: 311.0430

Molecular Weight: 311.25

Elemental Analysis: C, 61.74; H, 2.91; N, 4.50; O, 30.84

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
Aristolochic acid B; Aristolochic acid II; CCRIS 6497; Q-100503; LS-102940; IIBRN-0329754; CCRIS6497; Q100503; LS-102940; IIBRN-0329754
IUPAC/Chemical Name
6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
InChi Key
MEEXETVZNQYRSP-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
SMILES Code
O=C(C1=C(C([N+]([O-])=O)=CC2=CC=CC=C23)C3=C(OCO4)C4=C1)O
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 311.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bárta F, Dedíková A, Bebová M, Dušková Š, Mráz J, Schmeiser HH, Arlt VM, Hodek P, Stiborová M. Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats. Int J Mol Sci. 2021 Sep 28;22(19):10479. doi: 10.3390/ijms221910479. PMID: 34638820; PMCID: PMC8509051. 2: Liu Y, Han S, Feng Q, Wang J. [Determination of aristolochic acids A and B in Chinese herbals and traditional Chinese patent medicines using ultra high performance liquid chromatography-triple quadrupole mass spectrometry]. Se Pu. 2011 Nov;29(11):1076-81. Chinese. PMID: 22393694. 3: Mou ZL, Qi XN, Liu RL, Zhang J, Zhang ZQ. Three-dimensional cell bioreactor coupled with high performance liquid chromatography-mass spectrometry for the affinity screening of bioactive components from herb medicine. J Chromatogr A. 2012 Jun 22;1243:33-8. doi: 10.1016/j.chroma.2012.04.041. Epub 2012 Apr 19. PMID: 22554414.