SB 272183 | CAS#216058-27-4

MedKoo Cat#: 532661 | Name: SB 272183

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB 272183 is a highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drug.

Chemical Structure

SB 272183

CAS#216058-27-4

Theoretical Analysis

MedKoo Cat#: 532661

Name: SB 272183

CAS#: 216058-27-4

Chemical Formula: C29H28ClN5O

Exact Mass: 497.1982

Molecular Weight: 498.03

Elemental Analysis: C, 69.94; H, 5.67; Cl, 7.12; N, 14.06; O, 3.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SB 272183; SB272183; SB-272183.

IUPAC/Chemical Name

5-chloro-6-(4-methylpiperazin-1-yl)-N-(4-pyridin-4-ylnaphthalen-1-yl)-2,3-dihydroindole-1-carboxamide

InChi Key

DAPBIPAGJXKFCI-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H28ClN5O/c1-33-14-16-34(17-15-33)28-19-27-21(18-25(28)30)10-13-35(27)29(36)32-26-7-6-22(20-8-11-31-12-9-20)23-4-2-3-5-24(23)26/h2-9,11-12,18-19H,10,13-17H2,1H3,(H,32,36)

SMILES Code

O=C(N1CCC2=C1C=C(N3CCN(C)CC3)C(Cl)=C2)NC4=C5C=CC=CC5=C(C6=CC=NC=C6)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 498.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kling A, Lange UE, Mack H, Bakker MH, Drescher KU, Hornberger W, Hutchins CW, Möller A, Müller R, Schmidt M, Unger L, Wicke K, Schellhaas K, Steiner G. Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5567-73. Epub 2005 Oct 10. PubMed PMID: 16219465. 2: Wyman PA, Marshall HR, Flynn ST, King RJ, Thompson M, Smith PW, Hadley MS, Price GW, Scott CM, Dawson LA. Identification of a potent and selective 5-HT1B receptor antagonist. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4708-12. PubMed PMID: 16153839. 3: Watson J, Roberts C, Scott C, Kendall I, Collin L, Day NC, Harries MH, Soffin E, Davies CH, Randall AD, Heightman T, Gaster L, Wyman P, Parker C, Price GW, Middlemiss DN. SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol. 2001 Jul;133(6):797-806. PubMed PMID: 11454652; PubMed Central PMCID: PMC1572841.