RTI-118 | CAS#847554-50-1 |Neuropeptide S receptor Antagonist

MedKoo Cat#: 532594 | Name: RTI-118

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RTI-118 is an antagonist of the neuropeptide S receptor.

Chemical Structure

RTI-118

CAS#847554-50-1

Theoretical Analysis

MedKoo Cat#: 532594

Name: RTI-118

CAS#: 847554-50-1

Chemical Formula: C26H32N4O3

Exact Mass: 448.2474

Molecular Weight: 448.57

Elemental Analysis: C, 69.62; H, 7.19; N, 12.49; O, 10.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

RTI-118; RTI 118; RTI118.

IUPAC/Chemical Name

3-oxo-1,1-di(phenyl)-N-(2-piperidin-1-ylethyl)-5,6,8,8a-tetrahydro-[1,3]oxazolo[4,3-c]pyrazine-7-carboxamide

InChi Key

JJDDRYMIPIEXKX-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H32N4O3/c31-24(27-14-17-28-15-8-3-9-16-28)29-18-19-30-23(20-29)26(33-25(30)32,21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-2,4-7,10-13,23H,3,8-9,14-20H2,(H,27,31)

SMILES Code

O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCCN5CCCCC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 448.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bonano JS, Runyon SP, Hassler C, Glennon RA, Stevens Negus S. Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats. Eur J Pharmacol. 2014 Nov 15;743:98-105. doi: 10.1016/j.ejphar.2014.09.006. Epub 2014 Sep 16. PubMed PMID: 25220242; PubMed Central PMCID: PMC4259821. 2: Schmoutz CD, Zhang Y, Runyon SP, Goeders NE. Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats. Pharmacol Biochem Behav. 2012 Dec;103(2):332-7. doi: 10.1016/j.pbb.2012.09.003. Epub 2012 Sep 12. PubMed PMID: 22982682; PubMed Central PMCID: PMC3494782.