Synonym
GNE-955; GNE 955; GNE955.
IUPAC/Chemical Name
(S)-1-(2-methoxy-5-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)piperidin-3-amine
InChi Key
ASRHSBIEFUFSJR-KRWDZBQOSA-N
InChi Code
InChI=1S/C23H25N7O/c1-15-10-25-13-20(28-15)19-9-21-16(11-26-19)12-27-30(21)18-5-6-23(31-2)22(8-18)29-7-3-4-17(24)14-29/h5-6,8-13,17H,3-4,7,14,24H2,1-2H3/t17-/m0/s1
SMILES Code
CC1=NC(C2=NC=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=C4)C3=C2)=CN=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Pim kinases have been identified as promising therapeutic targets for hematologic-oncology indications, including multiple myeloma and certain leukemia.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
415.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wang X, Kolesnikov A, Tay S, Chan G, Chao Q, Do S, Drummond J, Ebens AJ, Liu
N, Ly JQ, Harstad E, Hu H, Moffat JG, Munugalavadla V, Murray JM, Slaga D, Tsui
V, Volgraf M, Wallweber HJA, Chang JH. Discovery of 5-Azaindazole (GNE-955) as a
Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 Apr 26.
doi: 10.1021/acs.jmedchem.7b00418. [Epub ahead of print] PubMed PMID: 28445037.
