RN1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). RN1734 displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). It blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.
MedKoo Cat#: 532544
Name: RN1734
CAS#: 946387-07-1
Chemical Formula: C14H22Cl2N2O2S
Exact Mass: 352.0779
Molecular Weight: 353.30
Elemental Analysis: C, 47.59; H, 6.28; Cl, 20.07; N, 7.93; O, 9.06; S, 9.07
The following data is based on the product molecular weight 353.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
