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MedKoo Cat#: 530607 | Name: GSK1702934A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK1702934A is an activator of transient receptor potential canonical 3 (TRPC3) and TRPC6. It induces TRPC3- and TRPC6-dependent currents in whole-cell patch-clamp assays using HEK293 cells expressing the human channels (EC50s = 0.08 and 0.44 µM, respectively). GSK1702934A enhances contractility and induces arrhythmias in hearts isolated from TRPC3-overexpressing, but not wild-type, mice.

Chemical Structure

GSK1702934A
GSK1702934A
CAS# 924377-85-5

Theoretical Analysis

MedKoo Cat#: 530607

Name: GSK1702934A

CAS#: 924377-85-5

Chemical Formula: C22H25N3O2S

Exact Mass: 395.1667

Molecular Weight: 395.52

Elemental Analysis: C, 66.81; H, 6.37; N, 10.62; O, 8.09; S, 8.11

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
GSK1702934A; GSK 1702934A; GSK-1702934A; GSK1702934; GSK 1702934; GSK-1702934;
IUPAC/Chemical Name
1-(1-(5,6,7,8-Tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl)-1H-benzo[d]- imidazole-2(3H)-one
InChi Key
AXWRAIIIBRLXBP-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H25N3O2S/c26-21(20-14-15-6-2-1-3-9-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(18)23-22(25)27/h4-5,7-8,14,16H,1-3,6,9-13H2,(H,23,27)
SMILES Code
O=C1N(C2CCN(C(C3=CC(CCCCC4)=C4S3)=O)CC2)C5=CC=CC=C5N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
TRPC3 is a non-selective cation channel, which forms a Ca2+ entry pathway involved in cardiac remodelling. Our aim was to analyse acute electrophysiological and contractile consequences of TRPC3 activation in the heart.
Solvent mg/mL mM
Solubility
DMSO 30.0 75.85
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 395.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Q, Tan YQ, Cheung KK, Chiu-Leung LC, Leung LK. The mycoestrogen zeranol at high dosage antagonizes transient receptor potential channel activities in 3T3 L1 cells. Toxicol Lett. 2021 Jun 15;344:18-25. doi: 10.1016/j.toxlet.2021.03.003. Epub 2021 Mar 6. PMID: 33689779. 2: Wang Y, Liu L, Tao H, Wen L, Qin S. TRPC6 participates in the development of blood pressure variability increase in sino-aortic denervated rats. Heart Vessels. 2020 Dec;35(12):1755-1765. doi: 10.1007/s00380-020-01682-1. Epub 2020 Aug 25. PMID: 32844288. 3: Fiedler S, Storch U, Erdogmus S, Gudermann T, Mederos Y Schnitzler M, Dietrich A. Small Fluorescein Arsenical Hairpin-Based Förster Resonance Energy Transfer Analysis Reveals Changes in Amino- to Carboxyl-Terminal Interactions upon OAG Activation of Classical Transient Receptor Potential 6. Mol Pharmacol. 2019 Jul;96(1):90-98. doi: 10.1124/mol.119.115949. PMID: 31171574. 4: Tiapko O, Shrestha N, Lindinger S, Guedes de la Cruz G, Graziani A, Klec C, Butorac C, Graier WF, Kubista H, Freichel M, Birnbaumer L, Romanin C, Glasnov T, Groschner K. Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem Sci. 2019 Jan 15;10(9):2837-2842. doi: 10.1039/c8sc05536j. PMID: 30997005; PMCID: PMC6427946. 5: Svobodova B, Lichtenegger M, Platzer D, Di Giuro CML, de la Cruz GG, Glasnov T, Schreibmayer W, Groschner K. A single point mutation in the TRPC3 lipid- recognition window generates supersensitivity to benzimidazole channel activators. Cell Calcium. 2019 May;79:27-34. doi: 10.1016/j.ceca.2019.02.007. Epub 2019 Feb 16. PMID: 30798155. 6: Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc Res. 2015 Apr 1;106(1):163-73. doi: 10.1093/cvr/cvv022. Epub 2015 Jan 28. PMID: 25631581; PMCID: PMC4362401.