QO-58 is a Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). QO-58 increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.
MedKoo Cat#: 532484
Name: QO-58
CAS#: 1259536-62-3
Chemical Formula: C18H8Cl2F4N4O
Exact Mass: 442.0000
Molecular Weight: 443.18
Elemental Analysis: C, 48.78; H, 1.82; Cl, 16.00; F, 17.15; N, 12.64; O, 3.61
The following data is based on the product molecular weight 443.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
