MedKoo Cat#: 558271 | Name: MDK77754
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK77754, also known as GPR120 Compound A, is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). MDK77754 has CAS#1599477-75-4. For the convenience of communication, we name it as MDK77754. The last 5 digit of CAS# was used in its name.

Chemical Structure

MDK77754
MDK77754
CAS#1599477-75-4

Theoretical Analysis

MedKoo Cat#: 558271

Name: MDK77754

CAS#: 1599477-75-4

Chemical Formula: C19H23ClF3NO3

Exact Mass: 405.1319

Molecular Weight: 405.84

Elemental Analysis: C, 56.23; H, 5.71; Cl, 8.73; F, 14.04; N, 3.45; O, 11.83

Price and Availability

Size Price Availability Quantity
500mg USD 2,250.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 4,650.00 2 Weeks
5g USD 6,750.00 2 Weeks
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Related CAS #
No Data
Synonym
GPR120 Compound A; MDK77754; MDK-77754; MDK 77754; GPR120 cpdA.
IUPAC/Chemical Name
3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid
InChi Key
WUJVPELCYCESAP-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
SMILES Code
O=C(O)CC(CC1)CCC21CCN(C3=CC(OC(F)(F)F)=CC=C3Cl)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky JM. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7. doi: 10.1038/nm.3614. Epub 2014 Jul 6. PubMed PMID: 24997608; PubMed Central PMCID: PMC4126875.