ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. ML311 Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 will be a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors.
MedKoo Cat#: 407459
Name: ML311
CAS#: 315698-17-0
Chemical Formula: C23H24F3N3O
Exact Mass: 415.1871
Molecular Weight: 415.46
Elemental Analysis: C, 66.49; H, 5.82; F, 13.72; N, 10.11; O, 3.85
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMSO | 44.1 | 106.23 | ||
| Ethanol | 20.8 | 49.99 |
The following data is based on the product molecular weight 415.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
