MedKoo Cat#: 407454 | Name: MDK35833
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK35833, also known as Oct3/4-inducer-1, is a potent Oct3/4-inducer. MDK35833 can promot expression and stabilization of Oct3/4 and enhance its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine.

Chemical Structure

MDK35833
MDK35833
CAS#1016535-83-3

Theoretical Analysis

MedKoo Cat#: 407454

Name: MDK35833

CAS#: 1016535-83-3

Chemical Formula: C15H12FNO

Exact Mass: 241.0903

Molecular Weight: 241.27

Elemental Analysis: C, 74.68; H, 5.01; F, 7.87; N, 5.81; O, 6.63

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
250mg USD 525.00 2 Weeks
500mg USD 850.00 2 Weeks
1g USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
Oct3/4-inducer-1, MDK35833; MDK-35833; MDK 35833.
IUPAC/Chemical Name
4-[(4-Fluorophenyl)methoxy]-benzeneacetonitrile
InChi Key
PXFUNIXWNXRVEJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12FNO/c16-14-5-1-13(2-6-14)11-18-15-7-3-12(4-8-15)9-10-17/h1-8H,9,11H2
SMILES Code
N#CCC1=CC=C(OCC2=CC=C(F)C=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene transcription. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of CBP/P300 to chromatin and which offeres an opportunity for the development of protein-protein interaction inhibitors.

Preparing Stock Solutions

The following data is based on the product molecular weight 241.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Popp TA, Tallant C, Rogers C, Fedorov O, Brennan PE, Müller S, Knapp S, Bracher F. Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. J Med Chem. 2016 Oct 13;59(19):8889-8912. Epub 2016 Sep 27. PubMed PMID: 27673482.