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MedKoo Cat#: 540003 | Name: AK-7
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AK-7, also known as CS-3223 and GL-8955, is a SITR2 inhibitor that decreases brain atrophy and improves motor function in Huntington's disease models.

Chemical Structure

AK-7
CAS#420831-40-9

Theoretical Analysis

MedKoo Cat#: 540003

Name: AK-7

CAS#: 420831-40-9

Chemical Formula: C19H21BrN2O3S

Exact Mass: 436.0456

Molecular Weight: 437.35

Elemental Analysis: C, 52.18; H, 4.84; Br, 18.27; N, 6.41; O, 10.97; S, 7.33

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
AK-7; CS-3223; GL-8955; AK7; CS3223; GL8955; AK 7; CS 3223; GL 8955
IUPAC/Chemical Name
3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide
InChi Key
IYAYHZZWYNXHEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
SMILES Code
O=C(NC1=CC=CC(Br)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 437.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang X, Guan Q, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z. Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. Drug Des Devel Ther. 2015 May 7;9:2553-63. doi: 10.2147/DDDT.S81539. eCollection 2015. PubMed PMID: 26089639; PubMed Central PMCID: PMC4466888. 2: Guan Q, Wang M, Chen H, Yang L, Yan Z, Wang X. Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7. Exp Gerontol. 2016 Sep;82:19-29. doi: 10.1016/j.exger.2016.05.011. Epub 2016 May 25. PubMed PMID: 27235848. 3: Jung HY, Yoo DY, Kim JW, Kim DW, Choi JH, Chung JY, Won MH, Yoon YS, Hwang IK. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230. doi: 10.5625/lar.2016.32.4.224. Epub 2016 Dec 23. PubMed PMID: 28053616; PubMed Central PMCID: PMC5206229. 4: Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Cipicchio PM, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 Dec 27;2(6):1492-7. doi: 10.1016/j.celrep.2012.11.001. Epub 2012 Nov 29. PubMed PMID: 23200855; PubMed Central PMCID: PMC3534897. 5: Wang X, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z. Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake. Neural Regen Res. 2014 Nov 1;9(21):1917-22. doi: 10.4103/1673-5374.145361. PubMed PMID: 25558243; PubMed Central PMCID: PMC4281432. 6: Yuan F, Xu ZM, Lu LY, Nie H, Ding J, Ying WH, Tian HL. SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation. J Neurochem. 2016 Feb;136(3):581-93. doi: 10.1111/jnc.13423. Epub 2015 Dec 7. PubMed PMID: 26546505. 7: Deng YH, Pu CL, Li YC, Zhu J, Xiang C, Zhang MM, Guo CB. Analysis of biliary epithelial-mesenchymal transition in portal tract fibrogenesis in biliary atresia. Dig Dis Sci. 2011 Mar;56(3):731-40. doi: 10.1007/s10620-010-1347-6. Epub 2010 Aug 20. PubMed PMID: 20725787. 8: Kendall MM, Wardlaw GD, Tang CF, Bonin AS, Liu Y, Valentine DL. Diversity of Archaea in marine sediments from Skan Bay, Alaska, including cultivated methanogens, and description of Methanogenium boonei sp. nov. Appl Environ Microbiol. 2007 Jan;73(2):407-14. Epub 2006 Nov 22. PubMed PMID: 17122405; PubMed Central PMCID: PMC1796967. 9: Coles JA, Orkand RK. Changes in sodium activity during light stimulation in photoreceptors, glia and extracellular space in drone retina. J Physiol. 1985 May;362:415-35. PubMed PMID: 4020694; PubMed Central PMCID: PMC1192905. 10: Biella G, Fusco F, Nardo E, Bernocchi O, Colombo A, Lichtenthaler SF, Forloni G, Albani D. Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models. J Alzheimers Dis. 2016 Jun 30;53(3):1193-207. doi: 10.3233/JAD-151135. PubMed PMID: 27372638. 11: Lugrin J, Ciarlo E, Santos A, Grandmaison G, dos Santos I, Le Roy D, Roger T. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510. doi: 10.1016/j.bbamcr.2013.03.004. Epub 2013 Mar 13. PubMed PMID: 23499872.

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