Synonym
MTC420; MTC-420; MTC 420.
IUPAC/Chemical Name
2-(4-(3,3-difluoropyrrolidin-1-yl)phenyl)-5,7-difluoro-3-methylquinolin-4(1H)-one
InChi Key
FFUXCAUWEZSJRC-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16F4N2O/c1-11-18(25-16-9-13(21)8-15(22)17(16)19(11)27)12-2-4-14(5-3-12)26-7-6-20(23,24)10-26/h2-5,8-9H,6-7,10H2,1H3,(H,25,27)
SMILES Code
FC1=C2C(NC(C3=CC=C(N4CCC(F)(F)C4)C=C3)=C(C)C2=O)=CC(F)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
In 2014, tuberculosis (TB) globally infected 9.6 million people, resulting in an estimated 1.5 million deaths.1 With the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) TB, the need for new drug treatments targeting the disease has never been greater.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
376.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hong WD, Gibbons PD, Leung SC, Amewu R, Stocks PA, Stachulski AV, Horta PC,
Cristiano ML, Shone AE, Moss D, Ardrey A, Sharma R, Warman AJ, Bedingfield PT,
Fisher NE, Aljayyoussi G, Mead S, Caws M, Berry NG, Ward SA, Biagini GA, O'Neill
PM, Nixon GL. Rational Design, Synthesis and Biological Evaluation of
Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium
tuberculosis. J Med Chem. 2017 Mar 17. doi: 10.1021/acs.jmedchem.6b01718. [Epub
ahead of print] PubMed PMID: 28304162.
