ISCK03 | CAS#945526-43-2 | c-Kit inhibitor

MedKoo Cat#: 407436 | Name: ISCK03

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.

Chemical Structure

ISCK03

CAS#945526-43-2

Theoretical Analysis

MedKoo Cat#: 407436

Name: ISCK03

CAS#: 945526-43-2

Chemical Formula: C19H21N3O2S

Exact Mass: 355.1354

Molecular Weight: 355.46

Elemental Analysis: C, 64.20; H, 5.96; N, 11.82; O, 9.00; S, 9.02

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 1,950.00
1g	USD 3,050.00	2 Weeks

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Related CAS #

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Synonym

ISCK03; ISCK-03; ISCK 03.

IUPAC/Chemical Name

[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide

InChi Key

YKRCYYGZFGRSAX-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-6-17(7-5-15)22(25(23)24)18-10-8-16(9-11-18)21-13-12-20-14-21/h4-14,25H,1-3H3

SMILES Code

O=S(N(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(N3C=CN=C3)C=C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

ISCK03 is a specific SCF/c-Kit inhibitor.

In vitro activity:

The KIT inhibitor ISCK03 suppressed the production of hemoglobin in K562 cells but did not affect transcription of globin genes. Reference: Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118931. https://pubmed.ncbi.nlm.nih.gov/33340546/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	84.40
	DMF:PBS (pH 7.2) (1:5)	0.2	0.56
	DMSO	31.5	88.62
	Ethanol	2.0	5.63

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 355.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Hirano T, Tsuruda T, Tanaka Y, Harada H, Yamazaki T, Ishida A. Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins. Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118931. doi: 10.1016/j.bbamcr.2020.118931. Epub 2020 Dec 17. PMID: 33340546. 2. Ma J, Liu X, Chen H, Abbas MK, Yang L, Sun H, Sun T, Wu B, Yang S, Zhou D. c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression. Cancer Sci. 2021 Feb;112(2):655-667. doi: 10.1111/cas.14750. Epub 2020 Dec 19. PMID: 33247506; PMCID: PMC7894012.

In vitro protocol:

In vivo protocol:

TBD

1: Na YJ, Baek HS, Ahn SM, Shin HJ, Chang IS, Hwang JS. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep 1;74(5):780-6. Epub 2007 Jun 14. PubMed PMID: 17658483. 2: Kamlah F, Hänze J, Arenz A, Seay U, Hasan D, Juricko J, Bischoff B, Gottschald OR, Fournier C, Taucher-Scholz G, Scholz M, Seeger W, Engenhart-Cabillic R, Rose F. Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1541-9. doi: 10.1016/j.ijrobp.2011.03.033. Epub 2011 May 27. PubMed PMID: 21621345. 3: Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, Yamazaki T. Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7. PubMed PMID: 25928165; PubMed Central PMCID: PMC4423487.